Distribution and metabolism of hexadecylphosphocholine in mice

Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He‐PC) has been studied in mice. It is demonstrated that He‐PC is well‐absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of...

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Published inLipids Vol. 22; no. 11; pp. 925 - 926
Main Authors Breiser, A., Kim, D. ‐J., Fleer, E. A. M., Damenz, W., Drube, A., Berger, M., Nagel, G. A., Eibl, H., Unger, C.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.11.1987
Subjects
Administration, Oral
Animals
Choline - analogs & derivatives
Female
Mice
Phosphorylcholine - administration & dosage
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - pharmacokinetics
Tissue Distribution
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Summary:Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He‐PC) has been studied in mice. It is demonstrated that He‐PC is well‐absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2‐diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He‐PC breakdown.
Bibliography:Presented at the symposium on “Ether Lipids in Oncology,” Göttingen, Federal Republic of Germany, December 1986.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0024-4201
1558-9307
DOI:10.1007/BF02535556