Inhibitory Effects of Isolated Compounds from Black Coloured Rice Bran on the Complement Classical Pathway

• Published in: Phytotherapy research Vol. 25; no. 9; pp. 1418 - 1420
• Main Authors: Moon, Hyung-In, Lee, Jai-Heon, Lee, Young-Choon, Kim, Soo-Ki
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2011; Wiley
• Subjects: Animals; anticomplement activity; Biological and medical sciences; black coloured rice bran; classical pathway; Complement Pathway, Classical - drug effects; Erythrocytes; General pharmacology; Hydroxybenzoates - pharmacology; Inhibitory Concentration 50; Medical sciences; Oryza - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Quercetin - pharmacology; Rabbits; Sheep; classical pathway; Pharmacognosy; anticomplement activity; Plant origin; Anticomplementary activity; Complement; Medicinal plant; Rice; black coloured rice bran
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.3485

The present study evaluated the anticomplement effects of isolated compounds from black coloured rice bran in the classical pathway of the complement system. Using column chromatography, three compounds: oryzafuran, quercetin and protocatechuic acid, were isolated and evaluated for in vitro anticomplement activity. Oryzafuran showed the most potent inhibitory activity against the complement system, with 50% inhibitory concentration (IC50) values of 126.2 µg/mL. This is the first report of anticomplement activity of isolated compounds from black coloured rice bran. Copyright © 2011 John Wiley & Sons, Ltd.