Phenol Glycosides with In Vitro anti-Helicobacter pylori Activity from Hypericum erectum Thunb
To evaluate the anti‐Helicobacter pylori activity of Hypericum erectum methanol extracts in order to provide the primary evidence for their use in clinical practice. An ethyl acetate fraction of H. erectum suspension‐cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 38....
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Published in | Phytotherapy research Vol. 25; no. 9; pp. 1389 - 1391 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.09.2011
Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | To evaluate the anti‐Helicobacter pylori activity of Hypericum erectum methanol extracts in order to provide the primary evidence for their use in clinical practice. An ethyl acetate fraction of H. erectum suspension‐cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 38.7–63.2 μg/mL, comparable to metronidazole (MIC50 = 43.2 μg/mL). To further investigate the involved active compounds of the H. erectum extracts, four phenol glycosides were isolated for the current study: quercetin‐3′‐O‐β‐d‐galactopyranoside, quercetin‐3′‐O‐(2′′‐acetyl)‐β‐d‐glucopyranoside, 4,6‐dihydroxy‐2‐methoxyphenyl‐1‐O‐β‐d‐glucopyranoside and 4‐hydroxy‐2,6‐dimethoxyphenyl‐1‐O‐α‐l‐rhamnopyranosyl(1–6)‐β‐d‐glucopyranoside. The MIC50 values of 4,6‐dihydroxy‐2‐methoxyphenyl‐1‐O‐β‐d‐glucopyranoside and 4‐hydroxy‐2,6‐dimethoxyphenyl‐1‐O‐α‐l‐rhamnopyranosyl(1–6)‐β‐d‐glucopyranoside from ATCC43504 strains were 7.3 and 27.3 μg/mL, respectively. The other two phenol glycosides did not show anti‐H. pylori activity. The results of this work suggest that H. erectum has some therapeutic potential against H. pylori infection, which could be explored for patients with gastroduodenal disorders. Copyright © 2011 John Wiley & Sons, Ltd. |
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Bibliography: | Dong-A University istex:A4E866BEFC5BBE1332DD7DB41FDDA75BEF469897 ark:/67375/WNG-NT8T7P09-F ArticleID:PTR3453 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0951-418X 1099-1573 |
DOI: | 10.1002/ptr.3453 |