Polymorphisms of GSTT1 and related genes in head and neck cancer risk

• Published in: Head & neck Vol. 26; no. 1; pp. 63 - 70
• Main Authors: Evans, Adam J., Henner, William David, Eilers, Kristi M., Montalto, Michelle A., Wersinger, Emily M., Andersen, Peter E., Cohen, James I., Everts, Edwin C., McWilliams, Jeffrey E., Beer, Tomasz M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2004; John Wiley & Sons
• Subjects: Aged; Biological and medical sciences; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - genetics; Case-Control Studies; CYP1A1; epidemology; European Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase - genetics; glutathione transferases; GSTM1; GSTP1; GSTT1; head and neck cancer; Head and Neck Neoplasms - epidemiology; Head and Neck Neoplasms - genetics; Humans; Male; Medical sciences; Middle Aged; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Polymorphism, Genetic; Risk Factors; Sex Factors; Smoking - epidemiology; Tumors; Human; GSTM1; Enzyme; Stomatology; Transferases; GSTP1; glutathione transferases; Risk; GSTT1; Epidemiology; Gene; Glutathione transferase; Risk factor; CYP1A1; ENT disease; Head and neck cancer; Polymorphism
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.10342

Background. Glutathione S‐transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Method. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population‐based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1–2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5–6.3) and men (OR, 1.2; CI, 0.7–2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women. © 2004 Wiley Periodicals, Inc. Head Neck 26:63–70, 2004