Polymorphisms of GSTT1 and related genes in head and neck cancer risk
Background. Glutathione S‐transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and...
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Published in | Head & neck Vol. 26; no. 1; pp. 63 - 70 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.01.2004
John Wiley & Sons |
Subjects | |
Online Access | Get full text |
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Summary: | Background. Glutathione S‐transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC).
Method. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population‐based controls.
Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1–2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5–6.3) and men (OR, 1.2; CI, 0.7–2.1) for the presence of GSTT1.
Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women. © 2004 Wiley Periodicals, Inc. Head Neck 26:63–70, 2004 |
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Bibliography: | istex:DFA1A4C1DC5014626528DBCA368B3B26E0BA1CFD ArticleID:HED10342 Grant R825282-01-0 from the Environmental Protection Agency and by grant 3M0l RR00334-33S2 from the National Center for Research Resources. ark:/67375/WNG-RX0JLXG4-5 A preliminary report of this data was presented in a poster at the American Association for Cancer Research in San Francisco, California, on April 8,2002, abstract #2019. |
ISSN: | 1043-3074 1097-0347 |
DOI: | 10.1002/hed.10342 |