5-Hydroxymethylfurfural from Black Garlic Extract Prevents TNFα-induced Monocytic Cell Adhesion to HUVECs by Suppression of Vascular Cell Adhesion Molecule-1 Expression, Reactive Oxygen Species Generation and NF-κB Activation

• Published in: Phytotherapy research Vol. 25; no. 7; pp. 965 - 974
• Main Authors: Kim, Hye Kyung, Choi, Young-Whan, Lee, Eun Na, Park, Jin Kyeong, Kim, Sun-Gun, Park, Da-Jung, Kim, Bong-Seon, Lim, Young-Tak, Yoon, Sik
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2011; Wiley
• Subjects: 5-hydroxymethylfurfural; aged black garlic; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; Cell Adhesion - drug effects; cell adhesion molecules; Cell Adhesion Molecules - antagonists & inhibitors; Cell Line; Furaldehyde - analogs & derivatives; Furaldehyde - pharmacology; Garlic - chemistry; General pharmacology; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1 - metabolism; Medical sciences; Monocytes - drug effects; NF-kappa B - antagonists & inhibitors; NF-κB transcription factor; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Vascular Cell Adhesion Molecule-1 - metabolism; Human; Endothelial cell; Reactive oxygen species; Vascular cell adhesion molecule 1; cell adhesion molecules; Monocyte; Pharmacognosy; Cytokine; Cell adhesion molecule; Furfural(hydroxymethyl); Extract; Medicinal plant; NF-kB transcription factor; aged black garlic; Cell adhesion; Plant origin; 5-hydroxymethylfurfural; human umbilical vein endothelial cells; Flavoring crop; Garlic; Transcription factor NFκB; Transcription factor; Umbilical vein; Tumor necrosis factor α

5‐Hydroxymethylfurfural (5‐HMF) is a common Maillard reaction product; the reaction occurs during heat‐processing and the preparation of many types of foods and beverages. Although 5‐HMF has been proposed to have harmful effects, recently, its beneficial effects, including antioxidant, cytoprotectiv...