Antioxidant activity of thiocholesterol on copper‐induced oxidation of low‐density lipoprotein

The effect of thiocholesterol (SH‐Chol) on the copper‐inducedin vitro oxidation of low‐density lipoprotein (LDL; 1.019<d<1.063) was investigated. Among the antioxidants tested, including cysteine, glutathione, 2‐mercaptoethanol, dithiothreitol, probucol, thiopalmitic acid,. and SH‐Chol, SH‐Cho...

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Bibliographic Details
Published inLipids Vol. 30; no. 4; pp. 321 - n/a
Main Authors Tanaka, Mitsuo, Nakagawa, Mitsuo
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.04.1995
Subjects
Antioxidants - pharmacology
Catalysis
Cholesterol - analogs & derivatives
Cholesterol - pharmacology
Copper - antagonists & inhibitors
Humans
In Vitro Techniques
Lipoproteins, LDL - drug effects
Lipoproteins, LDL - metabolism
Oxidation-Reduction
Solubility
Water - chemistry
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Summary:The effect of thiocholesterol (SH‐Chol) on the copper‐inducedin vitro oxidation of low‐density lipoprotein (LDL; 1.019<d<1.063) was investigated. Among the antioxidants tested, including cysteine, glutathione, 2‐mercaptoethanol, dithiothreitol, probucol, thiopalmitic acid,. and SH‐Chol, SH‐Chol was the most effective antioxidant in copper‐induced LDL oxidation. Also, SH‐Chol completely inhibited the formation oxysterols i.e., 7‐hydroxycholesterol and 7‐ketocholesterol, in LDL particles and reduced 1,1‐diphenyl‐2‐picrylhydrazyl used as stable free‐radical model. Moreover, SH‐Chol suppressed the degradation of endogenous α‐tocopherol in LDL particles. These findings indicate that SH‐Chol acts as antioxidant in the oxidative damage of LDLin vitro and as a free‐radical scavenger in lipid peroxidation.
Bibliography:ObjectType-Article-1
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ISSN:0024-4201
1558-9307
DOI:10.1007/BF02536039