Repeated exacerbations of ocular inflammation with vitreous hemorrhage in a patient with HLA-B27 associated uveitis

• Published in: The Journal of Medical Investigation Vol. 54; no. 3,4; pp. 350 - 353
• Main Authors: Kase, Satoru, Namba, Kenichi, Horie, Yukihiro, Kotake, Satoshi, Ohno, Shigeaki
• Format: Journal Article
• Language: English
• Published: Japan The University of Tokushima Faculty of Medicine 01.08.2007
• Subjects: Adult; corticosteroid; HLA-B27; HLA-B27 Antigen - metabolism; Humans; Male; Prednisolone - therapeutic use; Recurrence; Retinal Hemorrhage - etiology; Retinal Hemorrhage - immunology; Retinal Hemorrhage - pathology; uveitis; Uveitis - complications; Uveitis - drug therapy; Uveitis - immunology; Uveitis - pathology; vitreous hemorrhage; Vitreous Hemorrhage - etiology; Vitreous Hemorrhage - immunology; Vitreous Hemorrhage - pathology
• ISSN: 1343-1420; 1349-6867
• DOI: 10.2152/jmi.54.350

HLA-B27 associated uveitis is characterized by recurrent alternating acute unilateral attacks of intraocular inflammation in the anterior chamber. The aim of this study was to report an unusual case of repeated exacerbations with vitreous hemorrhage in HLA-B27 associated uveitis. Thirty four-year-old man was diagnosed as HLA-B27 associated uveitis in his right eye. He showed repeated exacerbation of ocular inflammation with retinal vein dilation and small retinal hemorrhage following vitreous hemorrhage. Fluorescein fundus angiography a week before the appearance of vitreous hemorrhage showed no neovascularization. Oral prednisolone administration was started from 40mg/day with gradual tapering. About 3 weeks after the onset, most of the vitreous hemorrhage disappeared and visual acuity was improved to 20/20. Through the decreased vitreous hemorrhage, Weiss ring was detected later. The vitreous hemorrhage found in this patient is a severe exacerbation, and might be a consequence of the vitritis that leads to posterior vitreous detachment. J. Med. Invest. 54: 350-353, August, 2007