Effects of a DMPC molecular film surrounding microbubbles on the sound-pressure threshold for collapse

Abstract We investigated the effects of a 1,2-dimyristoyl-sn-glycerol-3-phosphocholine (DMPC) molecular film surrounding microbubbles on their collapse under ultrasound irradiation. We defined the ejection of the internal gas from the microbubble (i.e. “daughter” bubbles) as bubble collapse. In part...

Full description

Saved in:
Bibliographic Details
Published inJapanese Journal of Applied Physics Vol. 62; no. SJ; p. SJ8006
Main Authors Kobayashi, Reina, Narita, Jun, Krafft, Marie Pierre, Koyama, Daisuke
Format Journal Article
LanguageEnglish
Published Tokyo IOP Publishing 01.07.2023
Japanese Journal of Applied Physics
Subjects
Bubbles
Contact angle
drug delivery system
microbubble
phospholipid
Sound
ultrasound
Online AccessGet full text

Cover

More Information
Summary:Abstract We investigated the effects of a 1,2-dimyristoyl-sn-glycerol-3-phosphocholine (DMPC) molecular film surrounding microbubbles on their collapse under ultrasound irradiation. We defined the ejection of the internal gas from the microbubble (i.e. “daughter” bubbles) as bubble collapse. In particular, we measured the sound-pressure thresholds for microbubble collapse in water and a DMPC solution. Bubbles with the DMPC film had a smaller resonance size than naked bubbles. The measured contact angles of the bubbles were lower after collapse, implying that DMPC molecules on the bubble surface partially desorbed between the processes of vibration and collapse.
Bibliography:JJAP-S1103100.R3
ISSN:0021-4922
1347-4065
DOI:10.35848/1347-4065/acbb83