Effect of prolonged emotional and pain stress on the content of methylcytosine-binding protein MeCP2 in nuclei of hippocampal neurons in rats with different excitability of the nervous system

In rats with low excitability threshold of the nervous system demonstrating significant and persistent behavioral disorders under stress conditions, the content of methylcytosine-binding protein MeCP2 in neuronal nuclei of hippocampal field CA3 decreased over 2 weeks after long-term emotional and pa...

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Published inBulletin of experimental biology and medicine Vol. 142; no. 2; pp. 239 - 241
Main Authors Dyuzhikova, N A, Savenko, Yu N, Sokolova, N E, Savvateeva-Popova, E V, Vaido, A I
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.08.2006
Subjects
Animals
Cell Nucleus - metabolism
Hippocampus - cytology
Male
Methyl-CpG-Binding Protein 2 - metabolism
Neurons - metabolism
Pain - metabolism
Rats
Rats, Wistar
Stress Disorders, Post-Traumatic - metabolism
Stress, Psychological - metabolism
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Summary:In rats with low excitability threshold of the nervous system demonstrating significant and persistent behavioral disorders under stress conditions, the content of methylcytosine-binding protein MeCP2 in neuronal nuclei of hippocampal field CA3 decreased over 2 weeks after long-term emotional and pain stress. It was hypothesized that protein MeCP2 triggers epigenetic changes in DNA that underlie "stress memory".
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0337-3