Effects of exposure to ozone on susceptibility to experimental tuberculosis

Exposure of mice to 1.96 mg/m3 ozone (O3) 3 h/day, 5 days/week, for up to 8 weeks beginning at 1 or 2 weeks after challenge with Mycobacterium tuberculosis R1Rv resulted in significant enhancement of bacterial titers in the lungs at 5 through 8 weeks after challenge when compared to mice exposed to...

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Bibliographic Details
Published inToxicology letters Vol. 9; no. 1; p. 11
Main Authors Thomas, G B, Fenters, J D, Ehrlich, R, Gardner, D E
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1981
Subjects
Animals
Female
Guinea Pigs
Lung - microbiology
Mice
Mice, Inbred C57BL
Ozone - toxicity
Time Factors
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - microbiology
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Summary:Exposure of mice to 1.96 mg/m3 ozone (O3) 3 h/day, 5 days/week, for up to 8 weeks beginning at 1 or 2 weeks after challenge with Mycobacterium tuberculosis R1Rv resulted in significant enhancement of bacterial titers in the lungs at 5 through 8 weeks after challenge when compared to mice exposed to filtered air. Exposure to lower concentrations of O3 did not produce any significant changes compared to controls. Exposure of guinea pigs to 2.9 mg/m3O3 for 3 h immediately after challenge with M. tuberculosis resulted in a suppression of the cutaneous delayed hypersensitivity response, without affecting the serum hemagglutination antibody titers. However, exposure of guinea pigs to 0.98 mg/m3 O3 3h/day for 5 days, initiated within 3 h after the infectious challenge, enhanced hemagglutination antibody titers initially, but the delayed hypersensitivity reaction did not differ from controls.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(81)90168-5