The impact of mutational burden, spliceosome and epigenetic regulator mutations on transfusion dependency in dysplastic neoplasms

Myelodysplastic neoplasms and dysplastic chronic myelomonocytic leukemia are characterized by cytopenia. Therefore, transfusion dependency is high in these dysplastic neoplasms. We investigated the impact of molecular genetics on the transfusion dependency in dysplastic neoplasms.

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Bibliographic Details
Published inJournal of laboratory medicine Vol. 49; no. 2; pp. 63 - 70
Main Authors Strasser, Bernhard, Mustafa, Sebastian, Steindl, Rita, Heibl, Sonja, Mandl, Johann, Lirk, Geald, Haushofer, Alexander
Format Journal Article
LanguageEnglish
Published De Gruyter 28.04.2025
Subjects
chronic myelomonocytic leukemia (CMML)
epigenetic regulator mutation
myelodysplastic neoplasm (MDS)
next-generation sequencing (NGS)
spliceosome mutation
transfusion
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Summary:Myelodysplastic neoplasms and dysplastic chronic myelomonocytic leukemia are characterized by cytopenia. Therefore, transfusion dependency is high in these dysplastic neoplasms. We investigated the impact of molecular genetics on the transfusion dependency in dysplastic neoplasms.
ISSN:2567-9430
2567-9449
DOI:10.1515/labmed-2024-0175