Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination Antibiogram

To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections b...

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Bibliographic Details
Published inInfection control and hospital epidemiology Vol. 27; no. 4; p. 413
Main Authors Mizuta, Mari, Linkin, Darren R, Nachamkin, Irving, Fishman, Neil O, Weiner, Mark G, Sheridan, Angela, Lautenbach, Ebbing
Format Journal Article
LanguageEnglish
Published United States 01.04.2006
Subjects
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Drug Resistance, Microbial
Drug Therapy, Combination
Hospitals, University
Humans
Microbial Sensitivity Tests
Philadelphia
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - drug therapy
Philadelphia
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Summary:To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections based on the 2 antibiograms did not differ substantively. Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam.
ISSN:0899-823X
DOI:10.1086/503175