Structure of the human ϰ-casein gene

The human ϰ-casein-encoding gene, Kca, was cloned and sequenced. The structural gene consists of five exons ranging from 33 to 496 nucleotides (nt) separated by introns ranging from 1146 to 2942 nt, and extends over 8821 nt. All intron/exon splice junctions conform to the GT/AG rule. The gene organi...

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Bibliographic Details
Published inGene Vol. 174; no. 1; pp. 65 - 69
Main Authors Edlund, Anders, Johansson, Thore, Leidvik, Brith, Hansson, Lennart
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 26.09.1996
Subjects
Alu sequence
Amino Acid Sequence
Base Sequence
Caseins - genetics
Female
Gene organization
Humans
Milk protein gene
Molecular Sequence Data
Nucleotide sequence
Regulatory sequences
Sequence Alignment
Sequence Analysis, DNA
Nucleotide sequence
nt
Kca
Gene organization
kDa
Regulatory sequences
bp
tsp
Alu sequence
UTR
kb
cDNA
PCR
Milk protein gene
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Summary:The human ϰ-casein-encoding gene, Kca, was cloned and sequenced. The structural gene consists of five exons ranging from 33 to 496 nucleotides (nt) separated by introns ranging from 1146 to 2942 nt, and extends over 8821 nt. All intron/exon splice junctions conform to the GT/AG rule. The gene organization is similar to that of the bovine gene. The 5′-flanking region contains an A+T-rich sequence; TTTAATT, close to where the TATA motif is found in most other genes, a CAAT box, and an AP-1 consensus sequence. In addition, one Alu repetitive element was found in the second intron.
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ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(96)00351-4