Karyotype analysis in acute nonlymphocytic leukemia (ANLL): Comparison with ethnic group, age, morphology, and survival

The karyotype, leukemic cell morphology (FAB classification), ethnic group, age, sex, and survival were compared in 60 patients with acute nonlymphocytic leukemia (ANLL), to determine their diagnostic and prognostic significance. An ethnic age difference was observed; a significantly greater number...

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Published inCancer genetics and cytogenetics Vol. 6; no. 3; pp. 187 - 199
Main Authors Bernstein, R., Pinto, M.R., Morcom, G., Macdougall, L.G., Bezwoda, W., Dukes, I., Penfold, G., Mendelow, B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1982
Subjects
Acute Disease
Adolescent
Adult
Age Factors
Aged
Child
Child, Preschool
Chromosome Aberrations
Chromosomes, Human, 13-15
Chromosomes, Human, 16-18
Chromosomes, Human, 21-22 and Y
Chromosomes, Human, 6-12 and X
Ethnic Groups
Female
Humans
Infant
Karyotyping
Leukemia - genetics
Leukemia - mortality
Male
Middle Aged
Translocation, Genetic
Trisomy
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Summary:The karyotype, leukemic cell morphology (FAB classification), ethnic group, age, sex, and survival were compared in 60 patients with acute nonlymphocytic leukemia (ANLL), to determine their diagnostic and prognostic significance. An ethnic age difference was observed; a significantly greater number of black patients were children. The majority of children were males. A higher frequency of chromosome abnormalities was detected in children, yet they survived longer than adults. A specific, significant association between a t(8; 21) karyotype and M2-ANLL was confirmed; four of ten patients with M2-ANLL showed this translocation. The more mature morphology of M2-ANLL was associated with a longer survival irrespective of karyotype, ethnic group, and age. The specificity of t(15; 17) in M3-ANLL and nonrandom monosomy 7 in preleukemic children was confirmed. Patients, particularly adults, with normal karyotypes tended to survive longer than those with abnormal karyotypes. The patient's age and the differentiative capacity of the leukemic cell appear to be as important as the karyotype in determining survival. The nonrandom association of certain chromosome aberrations in ANLL appears to be worldwide.
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ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(82)90056-5