Thermodynamic behaviour of membrane enzymes in Duchenne muscular dystrophy

Erythrocyte ghost preparations have been prepared from blood of Duchenne patients (DMD), female carriers of the disease and controls. Arrhenius plots of Na +,K +-ATPase activity of these membrane preparations show a biphasic response for controls. For 75% of DMD and carriers the response is monophas...

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Published inJournal of the neurological sciences Vol. 58; no. 1; pp. 143 - 151
Main Authors Austin, L., Katz, S., Jeffrey, P.L., Shield, L., Arthur, H., Mazzoni, M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 1983
Subjects
Acetylcholinesterase - blood
adenosinetriphosphatase
Duchenne's muscular dystrophy
Erythrocyte Membrane - enzymology
erythrocytes
Erythrocytes - enzymology
Female
Genetic Carrier Screening
Humans
Kinetics
Male
man
Muscular Dystrophies - enzymology
Muscular Dystrophies - genetics
Sodium-Potassium-Exchanging ATPase - blood
Temperature
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Summary:Erythrocyte ghost preparations have been prepared from blood of Duchenne patients (DMD), female carriers of the disease and controls. Arrhenius plots of Na +,K +-ATPase activity of these membrane preparations show a biphasic response for controls. For 75% of DMD and carriers the response is monophasic. This is not an inherent property of the membrane since it can vary over time in the one individual and it can be induced in normal membranes by preincubation with DMD plasma. Arrhenius plots of AChE activity showed no such difference between the three sources of blood.
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ISSN:0022-510X
1878-5883
DOI:10.1016/0022-510X(83)90117-X