A glycoconjugate-based gold nanoparticle approach for the targeted treatment of Pseudomonas aeruginosa biofilms

• Published in: Nanoscale Vol. 12; no. 45; pp. 23234 - 23240
• Main Authors: Zhang, Chao, Shi, De-Tai, Yan, Kai-Cheng, Sedgwick, Adam C., Chen, Guo-Rong, He, Xiao-Peng, James, Tony D., Ye, Bing, Hu, Xi-Le, Chen, Daijie
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 26.11.2020
• Subjects: Antibiotics; Biofilms; Carbohydrates; Drug delivery systems; Fluorescence; Fucose; Galactose; Glycoconjugates; Gold; Mass spectra; Metal Nanoparticles; Nanoparticles; NMR; Nuclear magnetic resonance; Pseudomonas aeruginosa; Virulence

In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs ( Fuc-AuNPs ) and galactose-based glycoconjugate AuNPs ( Gal-AuNPs ), respectively. Owing to the selective carbohydrate-based recognition of the k...