A glycoconjugate-based gold nanoparticle approach for the targeted treatment of Pseudomonas aeruginosa biofilms
In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs ( Fuc-AuNPs ) and galactose-based glycoconjugate AuNPs ( Gal-AuNPs ), respectively. Owing to the selective carbohydrate-based recognition of the k...
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| Published in | Nanoscale Vol. 12; no. 45; pp. 23234 - 23240 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
26.11.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (
Fuc-AuNPs
) and galactose-based glycoconjugate AuNPs (
Gal-AuNPs
), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of
P. aeruginosa
, LecB (fucose-specific lectin)/LecA (galactose-specific lectin),
Fuc-AuNPs
and
Gal-AuNPs
-based imaging and therapeutic strategies were evaluated towards
P. aeruginosa
. Both
Fuc-AuNPs
and
Gal-AuNPs
were non-covalently loaded with the fluorophore dicyanomethylene 4
H
-pyran (DCM) to afford two highly selective fluorescence imaging agents for the visualisation of
P. aeruginosa
. The loading of
Fuc-AuNPs
and
Gal-AuNPs
with the known antibiotic Ceftazidime (CAZ) exhibited an enhanced therapeutic effect, illustrating the significance of this targeted drug delivery strategy. Exploiting the phototherapeutic properties of AuNPs, photoirradiation (600 nm) of
Fuc-AuNP@CAZ/Gal-AuNP@CAZ
provided both photothermal and photodynamic therapeutic (PTT/PDT) effects, which facilitated the release of CAZ.
Fuc-AuNP@CAZ
and
Gal-AuNP@CAZ
were shown to be effective photo/chemotherapeutics resulting in almost complete eradication of
P. aeruginosa
biofilms formed on clinically relevant surfaces (glass slides and steel surface). |
|---|---|
| AbstractList | In this study, "core-shell" gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (Fuc-AuNPs) and galactose-based glycoconjugate AuNPs (Gal-AuNPs), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of P. aeruginosa, LecB (fucose-specific lectin)/LecA (galactose-specific lectin), Fuc-AuNPs and Gal-AuNPs-based imaging and therapeutic strategies were evaluated towards P. aeruginosa. Both Fuc-AuNPs and Gal-AuNPs were non-covalently loaded with the fluorophore dicyanomethylene 4H-pyran (DCM) to afford two highly selective fluorescence imaging agents for the visualisation of P. aeruginosa. The loading of Fuc-AuNPs and Gal-AuNPs with the known antibiotic Ceftazidime (CAZ) exhibited an enhanced therapeutic effect, illustrating the significance of this targeted drug delivery strategy. Exploiting the phototherapeutic properties of AuNPs, photoirradiation (600 nm) of Fuc-AuNP@CAZ/Gal-AuNP@CAZ provided both photothermal and photodynamic therapeutic (PTT/PDT) effects, which facilitated the release of CAZ. Fuc-AuNP@CAZ and Gal-AuNP@CAZ were shown to be effective photo/chemotherapeutics resulting in almost complete eradication of P. aeruginosa biofilms formed on clinically relevant surfaces (glass slides and steel surface).In this study, "core-shell" gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (Fuc-AuNPs) and galactose-based glycoconjugate AuNPs (Gal-AuNPs), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of P. aeruginosa, LecB (fucose-specific lectin)/LecA (galactose-specific lectin), Fuc-AuNPs and Gal-AuNPs-based imaging and therapeutic strategies were evaluated towards P. aeruginosa. Both Fuc-AuNPs and Gal-AuNPs were non-covalently loaded with the fluorophore dicyanomethylene 4H-pyran (DCM) to afford two highly selective fluorescence imaging agents for the visualisation of P. aeruginosa. The loading of Fuc-AuNPs and Gal-AuNPs with the known antibiotic Ceftazidime (CAZ) exhibited an enhanced therapeutic effect, illustrating the significance of this targeted drug delivery strategy. Exploiting the phototherapeutic properties of AuNPs, photoirradiation (600 nm) of Fuc-AuNP@CAZ/Gal-AuNP@CAZ provided both photothermal and photodynamic therapeutic (PTT/PDT) effects, which facilitated the release of CAZ. Fuc-AuNP@CAZ and Gal-AuNP@CAZ were shown to be effective photo/chemotherapeutics resulting in almost complete eradication of P. aeruginosa biofilms formed on clinically relevant surfaces (glass slides and steel surface). In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs ( Fuc-AuNPs ) and galactose-based glycoconjugate AuNPs ( Gal-AuNPs ), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of P. aeruginosa , LecB (fucose-specific lectin)/LecA (galactose-specific lectin), Fuc-AuNPs and Gal-AuNPs -based imaging and therapeutic strategies were evaluated towards P. aeruginosa . Both Fuc-AuNPs and Gal-AuNPs were non-covalently loaded with the fluorophore dicyanomethylene 4 H -pyran (DCM) to afford two highly selective fluorescence imaging agents for the visualisation of P. aeruginosa . The loading of Fuc-AuNPs and Gal-AuNPs with the known antibiotic Ceftazidime (CAZ) exhibited an enhanced therapeutic effect, illustrating the significance of this targeted drug delivery strategy. Exploiting the phototherapeutic properties of AuNPs, photoirradiation (600 nm) of Fuc-AuNP@CAZ/Gal-AuNP@CAZ provided both photothermal and photodynamic therapeutic (PTT/PDT) effects, which facilitated the release of CAZ. Fuc-AuNP@CAZ and Gal-AuNP@CAZ were shown to be effective photo/chemotherapeutics resulting in almost complete eradication of P. aeruginosa biofilms formed on clinically relevant surfaces (glass slides and steel surface). In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (Fuc-AuNPs) and galactose-based glycoconjugate AuNPs (Gal-AuNPs), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of P. aeruginosa, LecB (fucose-specific lectin)/LecA (galactose-specific lectin), Fuc-AuNPs and Gal-AuNPs-based imaging and therapeutic strategies were evaluated towards P. aeruginosa. Both Fuc-AuNPs and Gal-AuNPs were non-covalently loaded with the fluorophore dicyanomethylene 4H-pyran (DCM) to afford two highly selective fluorescence imaging agents for the visualisation of P. aeruginosa. The loading of Fuc-AuNPs and Gal-AuNPs with the known antibiotic Ceftazidime (CAZ) exhibited an enhanced therapeutic effect, illustrating the significance of this targeted drug delivery strategy. Exploiting the phototherapeutic properties of AuNPs, photoirradiation (600 nm) of Fuc-AuNP@CAZ/Gal-AuNP@CAZ provided both photothermal and photodynamic therapeutic (PTT/PDT) effects, which facilitated the release of CAZ. Fuc-AuNP@CAZ and Gal-AuNP@CAZ were shown to be effective photo/chemotherapeutics resulting in almost complete eradication of P. aeruginosa biofilms formed on clinically relevant surfaces (glass slides and steel surface). |
| Author | Chen, Guo-Rong Zhang, Chao Ye, Bing Chen, Daijie Hu, Xi-Le Sedgwick, Adam C. James, Tony D. Shi, De-Tai Yan, Kai-Cheng He, Xiao-Peng |
| Author_xml | – sequence: 1 givenname: Chao surname: Zhang fullname: Zhang, Chao organization: Emergency Department, Jinan Children's Hospital, Jinan City, China – sequence: 2 givenname: De-Tai surname: Shi fullname: Shi, De-Tai organization: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237 – sequence: 3 givenname: Kai-Cheng orcidid: 0000-0001-8869-7217 surname: Yan fullname: Yan, Kai-Cheng organization: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237 – sequence: 4 givenname: Adam C. orcidid: 0000-0002-3132-2913 surname: Sedgwick fullname: Sedgwick, Adam C. organization: Department of Chemistry, The University of Texas at Austin, Austin, USA – sequence: 5 givenname: Guo-Rong surname: Chen fullname: Chen, Guo-Rong organization: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237 – sequence: 6 givenname: Xiao-Peng orcidid: 0000-0002-8736-3511 surname: He fullname: He, Xiao-Peng organization: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237 – sequence: 7 givenname: Tony D. orcidid: 0000-0002-4095-2191 surname: James fullname: James, Tony D. organization: Department of Chemistry, University of Bath, Bath, U.K – sequence: 8 givenname: Bing surname: Ye fullname: Ye, Bing organization: Emergency Department, Jinan Children's Hospital, Jinan City, China – sequence: 9 givenname: Xi-Le surname: Hu fullname: Hu, Xi-Le organization: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237 – sequence: 10 givenname: Daijie surname: Chen fullname: Chen, Daijie organization: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33206087$$D View this record in MEDLINE/PubMed |
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| Snippet | In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (... In this study, "core-shell" gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs... In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs... |
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| SubjectTerms | Antibiotics Biofilms Carbohydrates Drug delivery systems Fluorescence Fucose Galactose Glycoconjugates Gold Mass spectra Metal Nanoparticles Nanoparticles NMR Nuclear magnetic resonance Pseudomonas aeruginosa Virulence |
| Title | A glycoconjugate-based gold nanoparticle approach for the targeted treatment of Pseudomonas aeruginosa biofilms |
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