The effect of ethanol on wheel running in rats

Rats were given IP injections of ethanol at 0, 400, 800 and 1200 mg/kg. Their activity in running wheels was recorded for one hour post-injection. Ethanol at 800 and 1200 mg/kg depressed running. This effect was greatest during the first 15 min post-injection when activity levels were highest in the...

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Bibliographic Details
Published inPharmacology, biochemistry and behavior Vol. 15; no. 5; pp. 819 - 821
Main Authors Duncan, Perry M., Baez, Ann M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1981
Subjects
Activity level
Animals
Dose-Response Relationship, Drug
Ethanol
Ethanol - pharmacology
Male
Motor Activity - drug effects
Rats
Time Factors
Wheel running
Wheel running
Ethanol
Activity level
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Summary:Rats were given IP injections of ethanol at 0, 400, 800 and 1200 mg/kg. Their activity in running wheels was recorded for one hour post-injection. Ethanol at 800 and 1200 mg/kg depressed running. This effect was greatest during the first 15 min post-injection when activity levels were highest in the nondrugged condition. No evidence of an ethanol-produced increase in running was seen. The monotonic, dose-related activity decrement with no biphasic effect from ethanol in wheel running is similar to some reports of this drug's effect on rats in other paradigms, such as food-motivated operant responding and spontaneous motor activity.
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(81)90028-9