Role of Glucocorticoid Receptor in Serosa-Involved Gastric Carcinoma After Gastrectomy

Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly...

Full description

Saved in:

Bibliographic Details
Published in	Journal of gastrointestinal surgery Vol. 10; no. 5; pp. 706 - 711
Main Authors	Yeh, Dah-Cherng, Cheng, Shao-Bin, Yu, Cheng-Chan, Ho, William-Lin, Wu, Cheng-Chung, Liu, Tse-Jia, P'eng, Fang-Ku
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.05.2006 Springer Nature B.V
Subjects	Adult Aged Aged, 80 and over Cancer Female Gastrectomy glucocorticoid receptor Humans Male Medical research Middle Aged Multivariate analysis Prognosis Proportional Hazards Models Receptors, Glucocorticoid - metabolism Serosa-involved gastric carcinoma Serous Membrane - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - surgery Survival Rate glucocorticoid receptor Serosa-involved gastric carcinoma gastrectomy prognosis
Online Access	Get full text

Cover

Loading…

Abstract	Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly serosa-involved gastric carcinoma were determined by the dextran-coated charcoal method. The clinicopathologic characteristics and long-term survival duration were compared in patients with GR-positive and GR-negative cancer cells. We found that GR could be detected in the cytosol of cancer cells in 31 (41.3%) of the gastric cancer patients with a median concentration of 18.5 (range, 1.03–73.9) fmol/mg protein. No significant differences could be found in any clinicopathologic characteristic between the patients with GR-positive and GR-negative cancers. After multivariate analysis, gross Borrmann's type, metastatic lymph node number, and GR positivity were the independent prognostic factors after gastrectomy for serosa-involved gastric carcinoma. GR-positive gastric cancer had a worse survival rate than GR-negative gastric cancer. Multimodality adjuvant therapies should be considered in patients with GR-positive serosa-involved gastric carcinoma.
AbstractList	Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly serosa-involved gastric carcinoma were determined by the dextran-coated charcoal method. The clinicopathologic characteristics and long-term survival duration were compared in patients with GR-positive and GR-negative cancer cells. We found that GR could be detected in the cytosol of cancer cells in 31 (41.3%) of the gastric cancer patients with a median concentration of 18.5 (range, 1.03-73.9) fmol/mg protein. No significant differences could be found in any clinicopathologic characteristic between the patients with GR-positive and GR-negative cancers. After multivariate analysis, gross Borrmann's type, metastatic lymph node number, and GR positivity were the independent prognostic factors after gastrectomy for serosa-involved gastric carcinoma. GR-positive gastric cancer had a worse survival rate than GR-negative gastric cancer. Multimodality adjuvant therapies should be considered in patients with GR-positive serosa-involved gastric carcinoma.[PUBLICATION ABSTRACT] Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly serosa-involved gastric carcinoma were determined by the dextran-coated charcoal method. The clinicopathologic characteristics and long-term survival duration were compared in patients with GR-positive and GR-negative cancer cells. We found that GR could be detected in the cytosol of cancer cells in 31 (41.3%) of the gastric cancer patients with a median concentration of 18.5 (range, 1.03-73.9) fmol/mg protein. No significant differences could be found in any clinicopathologic characteristic between the patients with GR-positive and GR-negative cancers. After multivariate analysis, gross Borrmann's type, metastatic lymph node number, and GR positivity were the independent prognostic factors after gastrectomy for serosa-involved gastric carcinoma. GR-positive gastric cancer had a worse survival rate than GR-negative gastric cancer. Multimodality adjuvant therapies should be considered in patients with GR-positive serosa-involved gastric carcinoma.
Author	Cheng, Shao-Bin Yu, Cheng-Chan Wu, Cheng-Chung P'eng, Fang-Ku Ho, William-Lin Liu, Tse-Jia Yeh, Dah-Cherng
Author_xml	– sequence: 1 givenname: Dah-Cherng surname: Yeh fullname: Yeh, Dah-Cherng – sequence: 2 givenname: Shao-Bin surname: Cheng fullname: Cheng, Shao-Bin – sequence: 3 givenname: Cheng-Chan surname: Yu fullname: Yu, Cheng-Chan – sequence: 4 givenname: William-Lin surname: Ho fullname: Ho, William-Lin – sequence: 5 givenname: Cheng-Chung surname: Wu fullname: Wu, Cheng-Chung email: he@vghtc.gov.tw – sequence: 6 givenname: Tse-Jia surname: Liu fullname: Liu, Tse-Jia – sequence: 7 givenname: Fang-Ku surname: P'eng fullname: P'eng, Fang-Ku
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/16713543$$D View this record in MEDLINE/PubMed
BookMark	eNp9kFtr3DAQRkVIaG79B6EYCn3zZkby9aUQlmYTCARyKX0TsjQuWmxrK9kL-feR8UIhD3ka8XHmonPOjgc3EGNXCCsELK63q78qhMmvOEAeoxVAdsTOsCpFmhW8OI5vqDHlef7nlJ2HsAXAErD6wk6xKFHkmThjv59cR4lrk003aaedH6121iRPpGk3Op_YIXkm74JK74e96_Zkko0Ko7c6WSuv7eB6ldy0I_klJz26_u2SnbSqC_T1UC_Y6-2vl_Vd-vC4uV_fPKRaVNWYmrLIGyxNA23DCYRoNRgBQgnVUlvqgsCUJlOYC97kxgBCXnPBlc4arTQXF-zHMnfn3b-Jwih7GzR1nRrITUEWZV0XWIsIfv8Abt3kh3ibREQuKuTZTGULpeOPg6dW7rztlX-TCHK2LrdysS5n63Marce2b4fhU9OT-d900ByBnwtA0cXekpdBWxo0GTsLk8bZzze8A4D5l2c
CitedBy_id	crossref_primary_10_1111_j_1440_1746_2007_05140_x crossref_primary_10_1007_s12253_009_9154_0 crossref_primary_10_3390_cancers13071649
Cites_doi	10.1096/fasebj.13.1.169 10.1002/jso.20226 10.1002/1097-0142(19891215)64:12<2552::AID-CNCR2820641224>3.0.CO;2-Y 10.1016/0024-3205(92)90635-3 10.1073/pnas.68.5.932 10.1002/hep.1840180524 10.1002/jso.2930580208 10.1016/S0021-9258(19)52451-6 10.1007/BF00294714 10.1182/blood.V56.6.1036.1036 10.1002/(SICI)1097-0142(20000415)88:8<1796::AID-CNCR6>3.0.CO;2-2 10.1111/j.1749-6632.1949.tb27297.x 10.1007/PL00011681 10.1067/msy.2002.118710 10.1007/BF01655804 10.1023/A:1026686705421 10.1210/edrv-8-2-185
ContentType	Journal Article
Copyright	2006 The Society for Surgery of the Alimentary Tract The Society for Surgery of the Alimentary Tract, Inc. 2006
Copyright_xml	– notice: 2006 The Society for Surgery of the Alimentary Tract – notice: The Society for Surgery of the Alimentary Tract, Inc. 2006
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7RV 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH K9. KB0 M0S M1P NAPCQ PQEST PQQKQ PQUKI PRINS 7X8
DOI	10.1016/j.gassur.2005.10.004
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Nursing and Allied Health Journals ProQuest - Health & Medical Complete保健、医学与药学数据库 ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central AUTh Library subscriptions: ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Pharma Collection ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central Nursing & Allied Health Premium ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest One Academic Eastern Edition MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 7X7 name: ProQuest - Health & Medical Complete保健、医学与药学数据库 url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1873-4626
EndPage	711
ExternalDocumentID	2790547481 10_1016_j_gassur_2005_10_004 16713543 S1091255X05007195
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K -5E -5G -BR -EM -Y2 -~C .86 .VR 06C 06D 0R~ 0VY 1B1 1N0 203 29K 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 3V. 4.4 406 408 40D 40E 53G 5GY 5VS 67Z 6NX 78A 7RV 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AAEDT AAFGU AAHNG AAIAL AAJKR AALRI AANXM AANZL AAQFI AAQXK AARHV AARTL AATNV AATVU AAUYE AAWCG AAXUO AAYFA AAYIU AAYQN AAYTO ABDZT ABECU ABFGW ABFTV ABHQN ABIPD ABJNI ABJOX ABKAS ABKCH ABMAC ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBYP ACGFS ACHSB ACHVE ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACTTH ACVWB ACWMK ACZOJ ADBBV ADHHG ADHIR ADINQ ADJJI ADKNI ADKPE ADMDM ADMUD ADOXG ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFJLC AFKRA AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQEE AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BDATZ BENPR BGNMA BKEYQ BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP D-I DDRTE DNIVK DPUIP EBD EBLON EBS EIOEI EJD EMOBN EN4 ESBYG EX3 F5P FDB FEDTE FERAY FFXSO FGOYB FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Q G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 HF~ HG5 HG6 HMCUK HMJXF HRMNR HVGLF HZ~ IHE IJ- IKXTQ IMOTQ IWAJR IXC IXD IXE IZQ I~X I~Z J-C J0Z JBSCW JZLTJ KDC KOV KPH LLZTM M1P M41 M4Y MA- N4W N9A NAPCQ NPVJJ NQ- NQJWS NU0 O9- O93 O9I O9J OAM P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 QOR QOS R2- R89 R9I RIG RNI ROL RPX RPZ RSV RZK S16 S1Z S27 S37 S3B SAP SDH SHX SISQX SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W48 WK8 WOW YLTOR Z45 Z5O Z7U Z7V Z7W Z7X Z82 Z83 Z87 ZMTXR ZOVNA AACDK AAJBT ABAKF ACAOD AEFQL AFBBN AFJKZ AGRTI AIGIU AITUG ALIPV AMRAJ CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI PRINS 7X8
ID	FETCH-LOGICAL-c388t-d765b17db0fb2e033fc0d303a3afef7c6e0d7d4a1532b5dd01059232ac4bcac23
IEDL.DBID	7X7
ISSN	1091-255X
IngestDate	Fri Aug 16 04:07:14 EDT 2024 Fri Sep 13 02:35:28 EDT 2024 Thu Sep 26 17:50:48 EDT 2024 Sat Sep 28 07:46:54 EDT 2024 Fri Feb 23 02:31:28 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	glucocorticoid receptor Serosa-involved gastric carcinoma gastrectomy prognosis
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c388t-d765b17db0fb2e033fc0d303a3afef7c6e0d7d4a1532b5dd01059232ac4bcac23
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	16713543
PQID	1112381243
PQPubID	1456359
PageCount	6
ParticipantIDs	proquest_miscellaneous_67996193 proquest_journals_1112381243 crossref_primary_10_1016_j_gassur_2005_10_004 pubmed_primary_16713543 elsevier_sciencedirect_doi_10_1016_j_gassur_2005_10_004
PublicationCentury	2000
PublicationDate	2006-05-01
PublicationDateYYYYMMDD	2006-05-01
PublicationDate_xml	– month: 05 year: 2006 text: 2006-05-01 day: 01
PublicationDecade	2000
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: New York
PublicationTitle	Journal of gastrointestinal surgery
PublicationTitleAlternate	J Gastrointest Surg
PublicationYear	2006
Publisher	Elsevier Inc Springer Nature B.V
Publisher_xml	– name: Elsevier Inc – name: Springer Nature B.V
References	Wu, Chen, Wu, Liu, P'eng (bib16) 1995; 42 Baxter, Tomkins (bib22) 1971; 68 Silberman (bib24) 2005; 90 Kanemasa, Ozawa, Konishi (bib27) 1999; 44 Ramos, Meilandt, Wang, Firestone (bib7) 1999; 13 World Health Organization (bib17) 1990 Kitamura, Beppu, Anai (bib26) 1995; 58 Taiwan Department of Health (bib1) 1999 Katai, Yoshimura, Maruyama, Sasako, Sano (bib3) 2000; 88 Maruyama, Okabayashi, Kinoshita (bib4) 1987; 11 Japanese Gastric Cancer Association (bib5) 1998; 1 Carlstedt-Duke, Wikstrom, Gustafsson (bib10) 1988 Lui, P'eng, Chang (bib6) 1993; 18 Ho, Wu, Yeh (bib19) 2002; 131 Maruyama, Sasako, Kinoshita, Sano, Katai, Okajima (bib15) 1995; 19 Wu, Wang, Chien (bib13) 1992; 51 Wu, Fang, Yang, Wu, Liu (bib14) 1992; 77 Mastrangelo, Malandrino, Riccardi, Longo, Ranelletti, Iacobelli (bib9) 1980; 56 Wu, Wang, Chang (bib12) 1989; 64 Lowry, Rosenbrough, Farr, Randall (bib21) 1951; 193 Kim, Yu, Lee (bib25) 2001; 48 Wu, Chen, Chang (bib2) 1997; 184 Gustafsson, Carlstedt-Duke, Poellinger (bib11) 1987; 8 Sobin, Wittekind (bib18) 1997 Scatchard (bib20) 1949; 51 Bloomfield, Smith, Peterson, Munck (bib8) 1981; 41 Sobin, Wittekind (bib23) 2002 6934012 - Blood. 1980 Dec;56(6):1036-40 10760754 - Cancer. 2000 Apr 15;88(8):1796-800 4396919 - Proc Natl Acad Sci U S A. 1971 May;68(5):932-7 3038508 - Endocr Rev. 1987 May;8(2):185-234 7844980 - J Surg Oncol. 1995 Feb;58(2):112-7 15895444 - J Surg Oncol. 2005 Jun 1;90(3):174-86; discussion 186-7 11677936 - Hepatogastroenterology. 2001 Sep-Oct;48(41):1227-30 7676695 - World J Surg. 1995 Jul-Aug;19(4):532-6 8847037 - Hepatogastroenterology. 1995 Nov-Dec;42(6):867-72 1406053 - Life Sci. 1992;51(17):1355-61 2819664 - Cancer. 1989 Dec 15;64(12):2552-6 7693573 - Hepatology. 1993 Nov;18(5):1167-74 14907713 - J Biol Chem. 1951 Nov;193(1):265-75 3630186 - World J Surg. 1987 Aug;11(4):418-25 9179118 - J Am Coll Surg. 1997 Jun;184(6):611-7 9872941 - FASEB J. 1999 Jan;13(1):169-80 1399357 - Int Surg. 1992 Jul-Sep;77(3):144-8 10548361 - Dig Dis Sci. 1999 Oct;44(10):2081-7 11812959 - Surgery. 2002 Jan;131(1):19-25 6945909 - Cancer Res. 1981 Nov;41(11 Pt 2):4857-60 11957040 - Gastric Cancer. 1998 Dec;1(1):10-24 Lui (10.1016/j.gassur.2005.10.004_bib6) 1993; 18 Silberman (10.1016/j.gassur.2005.10.004_bib24) 2005; 90 Taiwan Department of Health (10.1016/j.gassur.2005.10.004_bib1) 1999 Mastrangelo (10.1016/j.gassur.2005.10.004_bib9) 1980; 56 Maruyama (10.1016/j.gassur.2005.10.004_bib15) 1995; 19 Katai (10.1016/j.gassur.2005.10.004_bib3) 2000; 88 Baxter (10.1016/j.gassur.2005.10.004_bib22) 1971; 68 Maruyama (10.1016/j.gassur.2005.10.004_bib4) 1987; 11 Japanese Gastric Cancer Association (10.1016/j.gassur.2005.10.004_bib5) 1998; 1 Kanemasa (10.1016/j.gassur.2005.10.004_bib27) 1999; 44 Kim (10.1016/j.gassur.2005.10.004_bib25) 2001; 48 Wu (10.1016/j.gassur.2005.10.004_bib12) 1989; 64 Carlstedt-Duke (10.1016/j.gassur.2005.10.004_bib10) 1988 Wu (10.1016/j.gassur.2005.10.004_bib2) 1997; 184 Ramos (10.1016/j.gassur.2005.10.004_bib7) 1999; 13 Gustafsson (10.1016/j.gassur.2005.10.004_bib11) 1987; 8 Lowry (10.1016/j.gassur.2005.10.004_bib21) 1951; 193 Wu (10.1016/j.gassur.2005.10.004_bib16) 1995; 42 Bloomfield (10.1016/j.gassur.2005.10.004_bib8) 1981; 41 Wu (10.1016/j.gassur.2005.10.004_bib13) 1992; 51 Scatchard (10.1016/j.gassur.2005.10.004_bib20) 1949; 51 Sobin (10.1016/j.gassur.2005.10.004_bib23) 2002 Ho (10.1016/j.gassur.2005.10.004_bib19) 2002; 131 Sobin (10.1016/j.gassur.2005.10.004_bib18) 1997 World Health Organization (10.1016/j.gassur.2005.10.004_bib17) 1990 Wu (10.1016/j.gassur.2005.10.004_bib14) 1992; 77 Kitamura (10.1016/j.gassur.2005.10.004_bib26) 1995; 58
References_xml	– volume: 51 start-page: 1355 year: 1992 end-page: 1361 ident: bib13 article-title: Regulation of arginase production by glucocorticoid in three human gastric cancer cell-lines publication-title: Life Science contributor: fullname: Chien – volume: 131 start-page: 19 year: 2002 end-page: 25 ident: bib19 article-title: Roles of the glucocorticoid receptor in resectable hepatocellular carcinoma publication-title: Surgery contributor: fullname: Yeh – year: 1999 ident: bib1 article-title: General Health Statistics: 1999, Taiwan Health and Vital Statistics contributor: fullname: Taiwan Department of Health – volume: 48 start-page: 1227 year: 2001 end-page: 1230 ident: bib25 article-title: Results of immunochemosurgery for gastric carcinoma publication-title: Hepatogastroenterology contributor: fullname: Lee – volume: 77 start-page: 144 year: 1992 end-page: 148 ident: bib14 article-title: Gastrectomy for advanced gastric carcinoma with invasion to the serosa publication-title: Int Surg contributor: fullname: Liu – volume: 44 start-page: 2081 year: 1999 end-page: 2087 ident: bib27 article-title: Distribution of glucocorticoid receptor immunoactivity in gastric mucosa of normal and adrenalectomized rat publication-title: Dig Dis Sci contributor: fullname: Konishi – start-page: 71 year: 1988 end-page: 83 ident: bib10 article-title: Structures, functional domains, and subcellular distribution of glucocorticoid receptor publication-title: Steroid Receptors in Health and Disease contributor: fullname: Gustafsson – year: 2002 ident: bib23 article-title: International Union against Cancer. TNM Classification of Malignant Tumors contributor: fullname: Wittekind – volume: 68 start-page: 932 year: 1971 end-page: 937 ident: bib22 article-title: Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells publication-title: Proc Natl Acad Sci U S A contributor: fullname: Tomkins – volume: 184 start-page: 611 year: 1997 end-page: 617 ident: bib2 article-title: Optimal surgical strategy for potentially curable serosa-involved gastric carcinoma with intraperitoneal free cancer cells publication-title: J Am Coll Surg contributor: fullname: Chang – year: 1997 ident: bib18 article-title: TNM Classification of Malignant Tumours contributor: fullname: Wittekind – volume: 90 start-page: 174 year: 2005 end-page: 187 ident: bib24 article-title: Perioperative adjuvant treatment in the management of operable gastric cancer publication-title: J Surg Oncol contributor: fullname: Silberman – volume: 88 start-page: 1796 year: 2000 end-page: 1800 ident: bib3 article-title: Evaluation of the new international union against cancer TNM staging for gastric carcinoma publication-title: Cancer contributor: fullname: Sano – volume: 42 start-page: 867 year: 1995 end-page: 872 ident: bib16 article-title: Cholelithiasis and cholecystitis after gastrectomy for gastric carcinoma: A comparison of lymphadenectomy of varying extent publication-title: Hepatogastroenterology contributor: fullname: P'eng – volume: 58 start-page: 112 year: 1995 end-page: 117 ident: bib26 article-title: Clinicopathologic study of patients with Borrmann type IV gastric carcinoma publication-title: J Surg Oncol contributor: fullname: Anai – volume: 193 start-page: 265 year: 1951 end-page: 275 ident: bib21 article-title: Protein measurement with Folin phenol reagent publication-title: J Biol Chem contributor: fullname: Randall – volume: 8 start-page: 185 year: 1987 end-page: 234 ident: bib11 article-title: Biochemistry, molecular biology, and physiology of the glucocorticoid receptor publication-title: Endocrine Rev contributor: fullname: Poellinger – volume: 1 start-page: 10 year: 1998 end-page: 24 ident: bib5 article-title: Japanese classifications of gastric carcinoma - 2nd English edition publication-title: Gastric Cancer contributor: fullname: Japanese Gastric Cancer Association – volume: 64 start-page: 2552 year: 1989 end-page: 2556 ident: bib12 article-title: Content of glucocorticoid receptor and arginase in gastric cancer and normal gastric mucosa tissues publication-title: Cancer contributor: fullname: Chang – volume: 18 start-page: 1167 year: 1993 end-page: 1174 ident: bib6 article-title: Analysis of glucocorticoid receptors in human hepatocellular carcinoma and hep G2 cells publication-title: Hepatology contributor: fullname: Chang – volume: 41 start-page: 4857 year: 1981 end-page: 4860 ident: bib8 article-title: Glucocorticoid receptors in adult lymphoblastic leukemia publication-title: Cancer Res contributor: fullname: Munck – volume: 56 start-page: 1036 year: 1980 end-page: 1040 ident: bib9 article-title: Clinical implications of glucocorticoid receptor studies in childhood acute lymphoblastic leukemia publication-title: Blood contributor: fullname: Iacobelli – volume: 51 start-page: 660 year: 1949 end-page: 672 ident: bib20 article-title: The attraction of proteins for small molecules and ions publication-title: Ann N Y Acad Sci contributor: fullname: Scatchard – volume: 19 start-page: 532 year: 1995 end-page: 536 ident: bib15 article-title: Pancreas-preserving total gastrectomy for proximal gastric cancer publication-title: World J Surg contributor: fullname: Okajima – volume: 11 start-page: 418 year: 1987 end-page: 425 ident: bib4 article-title: Progress in gastric cancer surgery in Japan and its limits of radicality publication-title: World J Surg contributor: fullname: Kinoshita – year: 1990 ident: bib17 publication-title: International Histological Classification of Tumors. Histological Typing of Esophageal and Gastric Tumors contributor: fullname: World Health Organization – volume: 13 start-page: 109 year: 1999 end-page: 180 ident: bib7 article-title: Dysfunctional glucocorticoid receptor with a single point mutation ablates the CCAAT/enhancer binding protein-dependent growth expression response in a steroid resistant hepatoma cell variant publication-title: FASEB J contributor: fullname: Firestone – volume: 13 start-page: 109 year: 1999 ident: 10.1016/j.gassur.2005.10.004_bib7 article-title: Dysfunctional glucocorticoid receptor with a single point mutation ablates the CCAAT/enhancer binding protein-dependent growth expression response in a steroid resistant hepatoma cell variant publication-title: FASEB J doi: 10.1096/fasebj.13.1.169 contributor: fullname: Ramos – volume: 90 start-page: 174 year: 2005 ident: 10.1016/j.gassur.2005.10.004_bib24 article-title: Perioperative adjuvant treatment in the management of operable gastric cancer publication-title: J Surg Oncol doi: 10.1002/jso.20226 contributor: fullname: Silberman – volume: 64 start-page: 2552 year: 1989 ident: 10.1016/j.gassur.2005.10.004_bib12 article-title: Content of glucocorticoid receptor and arginase in gastric cancer and normal gastric mucosa tissues publication-title: Cancer doi: 10.1002/1097-0142(19891215)64:12<2552::AID-CNCR2820641224>3.0.CO;2-Y contributor: fullname: Wu – volume: 51 start-page: 1355 year: 1992 ident: 10.1016/j.gassur.2005.10.004_bib13 article-title: Regulation of arginase production by glucocorticoid in three human gastric cancer cell-lines publication-title: Life Science doi: 10.1016/0024-3205(92)90635-3 contributor: fullname: Wu – volume: 68 start-page: 932 year: 1971 ident: 10.1016/j.gassur.2005.10.004_bib22 article-title: Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.68.5.932 contributor: fullname: Baxter – volume: 18 start-page: 1167 year: 1993 ident: 10.1016/j.gassur.2005.10.004_bib6 article-title: Analysis of glucocorticoid receptors in human hepatocellular carcinoma and hep G2 cells publication-title: Hepatology doi: 10.1002/hep.1840180524 contributor: fullname: Lui – volume: 77 start-page: 144 year: 1992 ident: 10.1016/j.gassur.2005.10.004_bib14 article-title: Gastrectomy for advanced gastric carcinoma with invasion to the serosa publication-title: Int Surg contributor: fullname: Wu – volume: 41 start-page: 4857 year: 1981 ident: 10.1016/j.gassur.2005.10.004_bib8 article-title: Glucocorticoid receptors in adult lymphoblastic leukemia publication-title: Cancer Res contributor: fullname: Bloomfield – volume: 58 start-page: 112 year: 1995 ident: 10.1016/j.gassur.2005.10.004_bib26 article-title: Clinicopathologic study of patients with Borrmann type IV gastric carcinoma publication-title: J Surg Oncol doi: 10.1002/jso.2930580208 contributor: fullname: Kitamura – volume: 193 start-page: 265 year: 1951 ident: 10.1016/j.gassur.2005.10.004_bib21 article-title: Protein measurement with Folin phenol reagent publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)52451-6 contributor: fullname: Lowry – volume: 48 start-page: 1227 year: 2001 ident: 10.1016/j.gassur.2005.10.004_bib25 article-title: Results of immunochemosurgery for gastric carcinoma publication-title: Hepatogastroenterology contributor: fullname: Kim – volume: 19 start-page: 532 year: 1995 ident: 10.1016/j.gassur.2005.10.004_bib15 article-title: Pancreas-preserving total gastrectomy for proximal gastric cancer publication-title: World J Surg doi: 10.1007/BF00294714 contributor: fullname: Maruyama – volume: 42 start-page: 867 year: 1995 ident: 10.1016/j.gassur.2005.10.004_bib16 article-title: Cholelithiasis and cholecystitis after gastrectomy for gastric carcinoma: A comparison of lymphadenectomy of varying extent publication-title: Hepatogastroenterology contributor: fullname: Wu – volume: 56 start-page: 1036 year: 1980 ident: 10.1016/j.gassur.2005.10.004_bib9 article-title: Clinical implications of glucocorticoid receptor studies in childhood acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood.V56.6.1036.1036 contributor: fullname: Mastrangelo – year: 2002 ident: 10.1016/j.gassur.2005.10.004_bib23 contributor: fullname: Sobin – start-page: 71 year: 1988 ident: 10.1016/j.gassur.2005.10.004_bib10 article-title: Structures, functional domains, and subcellular distribution of glucocorticoid receptor contributor: fullname: Carlstedt-Duke – volume: 88 start-page: 1796 year: 2000 ident: 10.1016/j.gassur.2005.10.004_bib3 article-title: Evaluation of the new international union against cancer TNM staging for gastric carcinoma publication-title: Cancer doi: 10.1002/(SICI)1097-0142(20000415)88:8<1796::AID-CNCR6>3.0.CO;2-2 contributor: fullname: Katai – volume: 51 start-page: 660 year: 1949 ident: 10.1016/j.gassur.2005.10.004_bib20 article-title: The attraction of proteins for small molecules and ions publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1949.tb27297.x contributor: fullname: Scatchard – year: 1990 ident: 10.1016/j.gassur.2005.10.004_bib17 contributor: fullname: World Health Organization – volume: 1 start-page: 10 year: 1998 ident: 10.1016/j.gassur.2005.10.004_bib5 article-title: Japanese classifications of gastric carcinoma - 2nd English edition publication-title: Gastric Cancer doi: 10.1007/PL00011681 contributor: fullname: Japanese Gastric Cancer Association – volume: 131 start-page: 19 year: 2002 ident: 10.1016/j.gassur.2005.10.004_bib19 article-title: Roles of the glucocorticoid receptor in resectable hepatocellular carcinoma publication-title: Surgery doi: 10.1067/msy.2002.118710 contributor: fullname: Ho – year: 1999 ident: 10.1016/j.gassur.2005.10.004_bib1 contributor: fullname: Taiwan Department of Health – year: 1997 ident: 10.1016/j.gassur.2005.10.004_bib18 contributor: fullname: Sobin – volume: 11 start-page: 418 year: 1987 ident: 10.1016/j.gassur.2005.10.004_bib4 article-title: Progress in gastric cancer surgery in Japan and its limits of radicality publication-title: World J Surg doi: 10.1007/BF01655804 contributor: fullname: Maruyama – volume: 184 start-page: 611 year: 1997 ident: 10.1016/j.gassur.2005.10.004_bib2 article-title: Optimal surgical strategy for potentially curable serosa-involved gastric carcinoma with intraperitoneal free cancer cells publication-title: J Am Coll Surg contributor: fullname: Wu – volume: 44 start-page: 2081 year: 1999 ident: 10.1016/j.gassur.2005.10.004_bib27 article-title: Distribution of glucocorticoid receptor immunoactivity in gastric mucosa of normal and adrenalectomized rat publication-title: Dig Dis Sci doi: 10.1023/A:1026686705421 contributor: fullname: Kanemasa – volume: 8 start-page: 185 year: 1987 ident: 10.1016/j.gassur.2005.10.004_bib11 article-title: Biochemistry, molecular biology, and physiology of the glucocorticoid receptor publication-title: Endocrine Rev doi: 10.1210/edrv-8-2-185 contributor: fullname: Gustafsson
SSID	ssj0017018
Score	1.8272684
Snippet	Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at...
SourceID	proquest crossref pubmed elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	706
SubjectTerms	Adult Aged Aged, 80 and over Cancer Female Gastrectomy glucocorticoid receptor Humans Male Medical research Middle Aged Multivariate analysis Prognosis Proportional Hazards Models Receptors, Glucocorticoid - metabolism Serosa-involved gastric carcinoma Serous Membrane - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - surgery Survival Rate
Title	Role of Glucocorticoid Receptor in Serosa-Involved Gastric Carcinoma After Gastrectomy
URI	https://dx.doi.org/10.1016/j.gassur.2005.10.004 https://www.ncbi.nlm.nih.gov/pubmed/16713543 https://www.proquest.com/docview/1112381243/abstract/ https://search.proquest.com/docview/67996193
Volume	10
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LS8NAEB58gHgR31ar7sHr0jS7efQkVZQiKCJWegv7ilRsUm0r-O-dySZ6Uo_ZPAgzszPfzM4D4CyxWppUKXRTneVSC8G1shFHpK9S09VaaKp3vr2LB0N5M4pGSzBoamEorbLRiZWitqWhGHkH9yRZl1CKjtIUBTDzzvn0jdP8KDpnrYdpLMNqN0RYgZKdjL5dL2o67oviel2OIHrUFNFVmV7PCFMX7z6-UmV6yd-M1G8gtDJG15uwUaNI1vds34IlV2zD2m19Tr4DTw_lq2NlzqqMdHQw8blybBmqNzdFL5uNC4ayV84UHxeooD6cZfh_1K2fGZouVJQTxar54X6dYvuTz10YXl89Xg54PUGBG5Gmc26TONJd5EeQ69AFQuQmsGi0lFC5yxMTu8AmVipUe6GOrKVxmYj4QmWkNsqEYg9WirJwB8Akeoq2p0WKXJdOS-US2ZNWxJY6pqVBC3hDsmzqG2VkTQbZS-ZJTDMvI1pFErcgaeia1cbeG_EMdfk_b7YbNmT1hptlP-LRgtPv27hV6PxDFa5czLI4QecOAWsL9j3zfn40pkmFUhz-_ekjWPcRGMp3bMPK_H3hjhGTzPVJJW4nsHpxdXf_gFfDsP8FDmDklw
link.rule.ids	315,786,790,12083,21416,27957,27958,31754,31755,33779,33780,43345,43840,74102,74659
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1JT-swEB5BkYALYnlAWX3gar00dpaeECBQWVohBKg3y1ue-gRJoS0S_55x7MAJuDqLrBl75pvF_gCOMqO4zqXEMNUayhVjVEmTUET6MtcdpZhy5537g7T3wK-GyTAk3CahrbKxibWhNpV2OfK_uCedd4k5Ox6_UMca5aqrgUJjHhY4w1ClBQun54Pbu886QhZ1_GG4bocieB42h-fqDq9_CE9nrz6vUnd48e-c03fgs3ZCF6uwEtAjOfHqXoM5W67DYj_Uxzfg8a56sqQqSN2JjoElvleNDEGzZscYXZNRSXDNVRNJRyUapjdrCM7P3dJPtGMVKqtnSWrecD_ucvrP73_g4eL8_qxHA3MC1SzPp9RkaaI6qIeoULGNGCt0ZNBZSSYLW2Q6tZHJDJdo7mKVGONoMhHpxVJzpaWO2Sa0yqq020A4Roimq1iO2uZWcWkz3uWGpcbdlJZHbaCNyMTYX5Ahms6x_8KL2HFdJm4URdyGrJGrCE7eO2-BNvyXL_caNYiw0Sbia1m04fDzMW4RV_eQpa1mE5FmGNQhUG3Dllfe10RTx1DI2c7Pvz6Epd59_0bcXA6ud2HZZ2Fcz-MetKavM7uPuGSqDsLi-wBGIeKt
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1JTxsxFH4qREJcKlq2FNr4wNViMvaMJ6eqLBEtJEIIUG6Wt0FBZSYlSaX-e57HHnKCXj2LLL_nt372B3AkrOamUArTVGcp14xRrWxGMdJXhelrzbQ_7zwa5xd3_Nckm0T80zzCKlub2BhqWxtfIz_GPem9S8rZcRlhEddnw--zP9QzSPlOa6TTWIOO4HmGGt45OR9f37z2FETSDwfjBn2KgfSkPUjXoL0eMFRdPocaS4P24m85qrcC0cYhDbfgY4wkyY8g-k_wwVWfYWMUe-XbcH9T_3akLkmDSsckE9-rp5agiXMzzLTJtCKof_Vc0WmFRuqvswTn52_sJ8YzDFX1kyINh3gY9_X9p387cDc8vz29oJFFgRpWFAtqRZ7pPsokKXXqEsZKk1h0XIqp0pXC5C6xwnKFpi_VmbWeMhOjvlQZro0yKduF9aqu3D4QjtmiHWhWoOS501w5wQfcstz6W9OKpAu0XTI5C5dlyBZF9ijDEnvey8yP4hJ3QbTrKqPDD45coj3_z5eHrRhk3HRzuVKRLvReH-N28T0QVbl6OZe5wAQPg9Yu7AXhrSaae7ZCzr68_-sebKDeyauf48sD2AwFGQ9_PIT1xfPSfcUQZaG_Rd17AdyL5uo
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+glucocorticoid+receptor+in+serosa-involved+gastric+carcinoma+after+gastrectomy&rft.jtitle=Journal+of+gastrointestinal+surgery&rft.au=Yeh%2C+Dah-Cherng&rft.au=Cheng%2C+Shao-Bin&rft.au=Yu%2C+Cheng-Chan&rft.au=Ho%2C+William-Lin&rft.date=2006-05-01&rft.issn=1091-255X&rft.volume=10&rft.issue=5&rft.spage=706&rft_id=info:doi/10.1016%2Fj.gassur.2005.10.004&rft_id=info%3Apmid%2F16713543&rft.externalDocID=16713543
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1091-255X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1091-255X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1091-255X&client=summon