Role of Glucocorticoid Receptor in Serosa-Involved Gastric Carcinoma After Gastrectomy

Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly...

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Published inJournal of gastrointestinal surgery Vol. 10; no. 5; pp. 706 - 711
Main Authors Yeh, Dah-Cherng, Cheng, Shao-Bin, Yu, Cheng-Chan, Ho, William-Lin, Wu, Cheng-Chung, Liu, Tse-Jia, P'eng, Fang-Ku
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2006
Springer Nature B.V
Subjects
Adult
Aged
Aged, 80 and over
Cancer
Female
Gastrectomy
glucocorticoid receptor
Humans
Male
Medical research
Middle Aged
Multivariate analysis
Prognosis
Proportional Hazards Models
Receptors, Glucocorticoid - metabolism
Serosa-involved gastric carcinoma
Serous Membrane - metabolism
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Survival Rate
glucocorticoid receptor
Serosa-involved gastric carcinoma
gastrectomy
prognosis
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Summary:Glucocorticoid receptor (GR) was first found in the cytosol of gastric cancer tissue more than 15 years ago. At present, most gastric cancers are diagnosed at the advanced stage. To elucidate the role of GR in gastric cancer, the GR levels of the cancer tissue of 75 consecutive patients with grossly serosa-involved gastric carcinoma were determined by the dextran-coated charcoal method. The clinicopathologic characteristics and long-term survival duration were compared in patients with GR-positive and GR-negative cancer cells. We found that GR could be detected in the cytosol of cancer cells in 31 (41.3%) of the gastric cancer patients with a median concentration of 18.5 (range, 1.03–73.9) fmol/mg protein. No significant differences could be found in any clinicopathologic characteristic between the patients with GR-positive and GR-negative cancers. After multivariate analysis, gross Borrmann's type, metastatic lymph node number, and GR positivity were the independent prognostic factors after gastrectomy for serosa-involved gastric carcinoma. GR-positive gastric cancer had a worse survival rate than GR-negative gastric cancer. Multimodality adjuvant therapies should be considered in patients with GR-positive serosa-involved gastric carcinoma.
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ISSN:1091-255X
1873-4626
DOI:10.1016/j.gassur.2005.10.004