Efficient preparation of ( Z)-alkenyl derivatives from ( Z)-vinyl ( N, N-diisopropyl)carbamate via Ni-catalysed coupling reactions
A ( Z)-vinyl ( N, N-diisopropyl)carbamate treated with Grignard reagents, under Wenkert Nickel-catalysed conditions, gave access to several substituted ( Z)-alkenyl derivatives. These Nickel-catalysed reactions, carried out with vinyl-, phenyl-, p-methoxyphenyl-, trimethylsilylmethylmagnesium bromid...
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Published in | Tetrahedron letters Vol. 44; no. 40; pp. 7553 - 7556 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
29.09.2003
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A (
Z)-vinyl (
N,
N-diisopropyl)carbamate treated with Grignard reagents, under Wenkert Nickel-catalysed conditions, gave access to several substituted (
Z)-alkenyl derivatives. These Nickel-catalysed reactions, carried out with vinyl-, phenyl-,
p-methoxyphenyl-, trimethylsilylmethylmagnesium bromide and benzylmagnesium chloride, led to the corresponding (
Z)-alkenyl derivatives in good yields and high stereoselectivities.
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(03)01804-5 |