Resistin, acute coronary syndrome and prognosis results from the atherogene study

• Published in: Atherosclerosis Vol. 193; no. 1; pp. 121 - 128
• Main Authors: LUBOS, Edith, MESSOW, Claudia M, MÜNZEL, Thomas, BLANKENBERG, Stefan, SCHNABEL, Renate, RUPPRECHT, Hans J, ESPINOLA-KLEIN, Christine, BICKEL, Christoph, PEETZ, Dirk, POST, Felix, LACKNER, Karl J, TIRET, Laurence
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 01.07.2007
• Subjects: Acute Disease; Aged; Angina Pectoris - blood; Angina, Unstable - blood; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Coronary Disease - blood; Coronary heart disease; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Electrocardiography; Female; Heart; Humans; Inflammation Mediators - blood; Lipids - blood; Male; Medical sciences; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - physiopathology; Prognosis; Resistin - blood; Risk Factors; Syndrome; Endocrinopathy; Myocardial infarction; Adipocyte; Pancreatic hormone; Renal function; Prognosis; Cardiovascular disease; Myocardial disease; Vascular disease; ST elevation; Pain; Atherosclerosis; Diagnosis; Impaired glucose tolerance; Resistin; Human; Cytokine; Angina pectoris; Coronary heart disease; Insulin; Treatment; Risk factor; Acute coronary syndrome; Variant angina; Macrophage
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2006.05.039

Resistin, an adipocyte and macrophage derived cytokine, causes insulin resistance and glucose intolerance. We investigated the impact of resistin as a diagnostic marker in patients with acute coronary syndrome and its prognostic value for future cardiovascular events. Resistin levels were determined in 1153 patients with stable angina (SAP), 380 patients with unstable angina, 278 patients with non-ST-elevation myocardial infarction (NSTEMI) and 111 patients with ST-elevation myocardial infarction (STEMI). All patients have been followed up for a median follow-up of 2.6 years. During follow-up, 70 patients died from cardiovascular causes. Compared to SAP, resistin levels (5.1 ng/mL in SAP) were elevated in patients with angina at rest (5.89 ng/mL, P=0.001), in patients with NSTEMI (6.00 ng/mL, P<0.001), and in patients with STEMI (5.98 ng/mL, P<0.001). Resistin levels rose at 3-6h after chest pain onset (5.46 ng/mL), persisted elevated among those individuals presenting between 6 and 12h after chest pain onset (5.57 ng/mL) and peaked in individuals presenting more than 12h after chest pain onset (5.74 ng/mL). An increase of one standard deviation of resistin levels was associated with a 1.22-fold (95% CI 1.04-1.43; P=0.02) risk for future fatal cardiovascular events in a model adjusted for risk factors and clinical and therapeutic variables. When adjustment for renal function was applied, this association lost its statistical significance. Resistin levels are elevated in patients presenting with unstable angina, NSTEMI and STEMI and might play a role as a diagnostic marker. In addition, systemic resistin level is moderately associated with future cardiovascular death in patients with documented coronary artery disease.