Diabetes-Related Fracture Risk Is Different in African Americans Compared With Hispanics and Caucasians

• Published in: The journal of clinical endocrinology and metabolism Vol. 104; no. 11; pp. 5729 - 5736
• Main Authors: Jain, Rajesh K, Weiner, Mark G, Zhao, Huaqing, Williams, Kevin Jon, Vokes, Tamara
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2019
• Subjects: African Americans; Body mass index; Comparative analysis; Diabetes; Diabetes mellitus; Electronic medical records; Fractures; Health care; Health risk assessment; Hip; Hispanic Americans; Hispanic people; Humerus; Hypertension; Medical records; Osteoporosis; Risk factors; Statistical analysis; Type 2 diabetes; Pennsylvania
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2019-00931

Diabetes mellitus (DM) has been associated with a 60% to 90% increased risk of fracture but few studies have been performed in African American and Hispanic subjects. The aim of the present study was to quantify the risk of incident major osteoporotic fractures (MOFs) of the hip, wrist, and humerus in African Americans, Hispanics, and Caucasians with DM compared with those with hypertension (HTN). We performed a retrospective cohort study of 19,153 subjects with DM (7618 Caucasians, 7456 African Americans, and 4079 Hispanics) and 26,217 with HTN (15,138 Caucasians, 8301 African Americans, and 2778 Hispanics) aged ≥40 years, treated at a large health care system in Philadelphia, Pennsylvania. All information about the subjects was obtained from electronic health records. The unadjusted MOF rates for each race/ethnicity were similar among those with DM and those with HTN (Caucasians, 1.85% vs 1.84%; African Americans, 1.07% vs 1.29%; and Hispanics, 1.69% vs 1.33%; P = NS for all). However, the MOF rates were higher for Caucasians and Hispanics with DM than for African Americans with DM (P < 0.01). In a multivariable model controlled for age, body mass index, sex, and previous MOF, DM was a statistically significant predictor of MOFs only for Caucasians and Hispanics [hazard ratio (HR), 1.23; 95% CI, 1.02 to 1.48; P = 0.026] but not for African Americans (HR, 0.92; 95% CI, 0.68 to 1.23; P = 0.56). Hispanics had a DM-related fracture risk similar to that of Caucasians, but AAs did not have an additional fracture risk conferred by DM.