The molecular mechanisms of severe typhoid fever

Salmonella typhi continues to cause severe disease in many parts of the world, its most feared complication being perforation of ulcerated Peyer's patches within the small intestine, leading to peritonitis with associated mortality. The pathogenesis of this process is not well understood. In th...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 9; no. 7; pp. 316 - 320
Main Authors Everest, P, Wain, J, Roberts, M, Rook, G, Dougan, G
Format Journal Article
LanguageEnglish
Published England 01.07.2001
Subjects
Enterotoxins - adverse effects
Humans
Peyer's Patches - pathology
Salmonella typhi
Salmonella typhi - physiology
Shwartzman Phenomenon
Typhoid Fever - immunology
Typhoid Fever - pathology
Typhoid Fever - physiopathology
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Summary:Salmonella typhi continues to cause severe disease in many parts of the world, its most feared complication being perforation of ulcerated Peyer's patches within the small intestine, leading to peritonitis with associated mortality. The pathogenesis of this process is not well understood. In this article, we present a theoretical mechanism as to how bacterial factors and host immunological mediators within infected tissue might contribute to the observed intestinal pathology, and propose that necrosis of the Peyer's patches observed in typhoid is caused by a mechanism similar to the Shwartzman and Koch reactions.
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ISSN:0966-842X
DOI:10.1016/S0966-842X(01)02067-4