The molecular mechanisms of severe typhoid fever
Salmonella typhi continues to cause severe disease in many parts of the world, its most feared complication being perforation of ulcerated Peyer's patches within the small intestine, leading to peritonitis with associated mortality. The pathogenesis of this process is not well understood. In th...
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Published in | Trends in microbiology (Regular ed.) Vol. 9; no. 7; pp. 316 - 320 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.07.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Salmonella typhi continues to cause severe disease in many parts of the world, its most feared complication being perforation of ulcerated Peyer's patches within the small intestine, leading to peritonitis with associated mortality. The pathogenesis of this process is not well understood. In this article, we present a theoretical mechanism as to how bacterial factors and host immunological mediators within infected tissue might contribute to the observed intestinal pathology, and propose that necrosis of the Peyer's patches observed in typhoid is caused by a mechanism similar to the Shwartzman and Koch reactions. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0966-842X |
DOI: | 10.1016/S0966-842X(01)02067-4 |