HLA-DR and HLA-DQ Polymorphism Correlation with Sexually Transmitted Infection Caused by Chlamydia trachomatis

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 5; p. 808
• Main Authors: Pintea-Trifu, Martina-Luciana, Vică, Mihaela Laura, Bâlici, Silvia-Ștefana, Leucuța, Daniel-Corneliu, Coman, Horia George, Nemeș, Bogdan, Trifu, Dragoș-Mihail, Siserman, Costel-Vasile, Matei, Horea-Vladi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.05.2024
• Subjects: Adolescent; Adult; Alleles; Antigens; Chlamydia; Chlamydia Infections - genetics; Chlamydia trachomatis; Female; Genes; Genetic Predisposition to Disease; Genetic testing; Genotype; Global health; Gonorrhea; Haplotypes; HLA antigens; HLA-DQ Antigens - genetics; HLA-DQB1; HLA-DR Antigens - genetics; HLA-DRB1; Hospitals; Humans; Infections; Informed consent; Male; MHC class II; Middle Aged; Pathogens; Patients; Personal information; Pharmacy; Polymorphism; Polymorphism, Genetic; Prospective Studies; Romania; Sexually transmitted diseases; Sexually Transmitted Diseases - genetics; STD; Syphilis; Transplants & implants; Tumor necrosis factor-TNF; Vagina; Romania; HLA antigens; sexually transmitted diseases; Chlamydia trachomatis; MHC class II; HLA-DRB1; HLA-DQB1
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60050808

: represents one of the most prevalent bacterial sexually transmitted diseases. This study aims to explore the relationship between HLA alleles/genotypes/haplotypes and infection to better understand high-risk individuals and potential complications. : This prospective study recruited participants from Transylvania, Romania. Patients with positive NAAT tests for from cervical/urethral secretion or urine were compared with controls regarding and alleles. DNA extraction for HLA typing was performed using venous blood samples. : Our analysis revealed that the presence of the DRB1*13 allele significantly heightened the likelihood of infection ( = 0.017). Additionally, we observed that individuals carrying the and genotype had increased odds of infection. Upon adjustment, the association between the genotype and remained statistically significant. : Our findings underscore the importance of specific alleles and genotypes in influencing susceptibility to infection. These results highlight the intricate relationship between host genetics and disease susceptibility, offering valuable insights for targeted prevention efforts and personalized healthcare strategies.