The carcinogenicity of N-nitrosodiethanolamine, an environmental pollutant, in Syrian hamsters

Weekly subcutaneous injections of N-nitrosodiethanolamine (NDELA) at doses of 1000, 500 and 250 mg/kg body wt for life induced tumors in Syrian hamsters which primarily affected the upper respiratory tract. The incidence of these malignant neoplasms arising exclusively from the olfactory region was...

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Bibliographic Details
Published inCancer letters Vol. 14; no. 1; pp. 23 - 27
Main Authors Pour, Parviz, Wallcave, Lawrence
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.01.1981
Subjects
Animals
Carcinogens
Cricetinae
Diethylnitrosamine - analogs & derivatives
Environmental Pollution
Female
Laryngeal Neoplasms - chemically induced
Male
Mesocricetus
Neoplasms, Experimental - chemically induced
Nitrosamines
Nose Neoplasms - chemically induced
Sex Factors
Tracheal Neoplasms - chemically induced
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Summary:Weekly subcutaneous injections of N-nitrosodiethanolamine (NDELA) at doses of 1000, 500 and 250 mg/kg body wt for life induced tumors in Syrian hamsters which primarily affected the upper respiratory tract. The incidence of these malignant neoplasms arising exclusively from the olfactory region was between 73% (highest dose) and 35% (lowest dose). Lower numbers of neoplasms were found with decreasing frequency in the trachea, larynx and lungs. The results indicate that doses of NDELA lower than 250 mg/kg body wt may also be carcinogenic. Hence, NDELA and its precursors should be regarded as hazardous to human health.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(81)90005-7