No longer an exclusive club: eukaryotic signalling domains in bacteria

Reversible phosphorylation of serine, threonine and tyrosine residues by the interplay of protein kinases and phosphatases plays a key role in regulating many different cellular processes in eukaryotic organisms. A diversity of control mechanisms exists to influence the activity of these enzymes and...

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Bibliographic Details
Published inTrends in cell biology Vol. 10; no. 1; pp. 32 - 38
Main Authors Bakal, C J, Davies, J E
Format Journal Article
LanguageEnglish
Published England 01.01.2000
Subjects
Bacterial Physiological Phenomena
phosphatase
Phosphorylation
Signal Transduction
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Summary:Reversible phosphorylation of serine, threonine and tyrosine residues by the interplay of protein kinases and phosphatases plays a key role in regulating many different cellular processes in eukaryotic organisms. A diversity of control mechanisms exists to influence the activity of these enzymes and choreograph the correct concert of protein modifications to achieve distinct biological responses. Such enzymes and their adaptor molecules were long thought to be specific to eukaryotic cellular processes. However, there is increasing evidence that many prokaryotes achieve regulation of key components of cellular function through similar mechanisms.
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ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(99)01681-5