A hypothesis on the mechanism of polyethylene glycol (PEG)-mediated membrane fusion

The authors present a hypothesis which can explain how PEG mediates membrane fusion. This hypothesis is based on the observation, that PEG is an amphiphilic substance which is soluble both in water and chloroform and therefore could act as a solvent for lipids.

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Bibliographic Details
Published inCell biology international reports Vol. 11; no. 7; p. 563
Main Authors Faisst, Steffen, Seibicke, Stefan
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.07.1987
Subjects
fusion
Lipid Bilayers - metabolism
Membrane Fusion - drug effects
Membrane Lipids - metabolism
Models, Biological
polyethylene glycol
Polyethylene Glycols - pharmacology
theories
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Summary:The authors present a hypothesis which can explain how PEG mediates membrane fusion. This hypothesis is based on the observation, that PEG is an amphiphilic substance which is soluble both in water and chloroform and therefore could act as a solvent for lipids.
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ISSN:0309-1651
1878-240X
DOI:10.1016/0309-1651(87)90019-1