Improvement of energy state and basic modifications of neuropathological damage in rabbits as a result of graded postischemic spinal cord reoxygenation

The role of graded postischemic reoxygenation applied at the end of 20 min of spinal cord ischemia was studied with respect to the intraspinal pO 2 tension, energy state, and histopathological sequelae. Graded postischemic reoxygenation can induce a positive shift in the intraspinal pO 2 tension, bu...

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Bibliographic Details
Published inExperimental neurology Vol. 105; no. 1; pp. 93 - 103
Main Authors Maršala, Martin, Danielisová, Viera, Chavko, Mikuláš, Horňáková, Anna, Maršala, Jozef
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.1989
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Summary:The role of graded postischemic reoxygenation applied at the end of 20 min of spinal cord ischemia was studied with respect to the intraspinal pO 2 tension, energy state, and histopathological sequelae. Graded postischemic reoxygenation can induce a positive shift in the intraspinal pO 2 tension, but normal postischemic reoxygenation with normotensive pO 2 blood tension inevitably causes the postischemic intraspinal pO 2 over-shoot. Graded postischemic reoxygenation significantly improves the energy state expressed by higher adenosine triphosphate (ATP), phosphocreatine (PCr) and glucose levels. Using the Nauta impregnating degenerating method, clear histopathological differences were found in the L 3–S 3 segments after 20 min of ischemia. Apparently divergent damage was observed when normal reoxygenation or graded postischemic reoxygenation was used. Diametrically different histopathological outcomes were obtained with normal reoxygenation and graded postischemic reoxygenation 2 and 4 days postoperatively.
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ISSN:0014-4886
1090-2430
DOI:10.1016/0014-4886(89)90176-3