Localization of neuroendocrine tumours with [111In]DTPA-octreotide scintigraphy (Octreoscan) : A comparative study with CT and MR imaging

• Published in: QJM : An International Journal of Medicine Vol. 91; no. 4; pp. 295 - 301
• Main Authors: SHI, W, JOHNSTON, C. F, BUCHANAN, K. D, FERGUSON, W. R, LAIRD, J. D, CROTHERS, J. G, MCILRATH, E. M
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.1998
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Carcinoid Tumor - diagnosis; Carcinoid Tumor - diagnostic imaging; Carcinoma, Medullary - diagnosis; Carcinoma, Medullary - diagnostic imaging; Child; Endocrine glands; Female; Humans; Indium Radioisotopes; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neuroendocrine Tumors - diagnosis; Neuroendocrine Tumors - diagnostic imaging; Octreotide - analogs & derivatives; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - diagnostic imaging; Pentetic Acid - analogs & derivatives; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radionuclide Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - diagnostic imaging; Tomography, X-Ray Computed; Endocrinopathy; Human; Evaluation; Octreotide; Nuclear magnetic resonance imaging; Analog; Neurohypophyseal hormone; Medical imagery; Specific identification; Computerized axial tomography; Somatostatin; Diagnosis; Emission transmission scintigraphy; Neuroendocrine tumor; Comparative study
• ISSN: 1460-2725; 1460-2393; 1460-2393
• DOI: 10.1093/qjmed/91.4.295

A wide variety of neuroendocrine tumours express somatostatin receptors, and can be visualized by radiolabelled somatostatin analogue scintigraphy. To investigate the value of [111In]-octreotide scintigraphy (Octreoscan), 48 patients (37 with proven carcinoid, pancreatic endocrine and medullary carcinoma of thyroid tumours, 11 with neuroendocrine syndromes multiple endocrine neoplasia (MEN-I) and Zollinger-Ellison syndrome (ZES) were examined with 111In-DTPA-D-Phe1-octreotide. Scintigrams were obtained at 24 and 48 h, and the results were compared with CT and magnetic resonance imaging (MRI). Thirty-five of 48 patients had positive [111In]-octreotide scintigraphy (23/25 (92%) carcinoids, 8/9 (89%) PETs, 4/11 (36%) MEN-I & ZES). Of the 42 lesions located by conventional imaging techniques, 37 (88%) were also identified by Octreoscan. Unexpected lesions (40 sites), not detected by CT or MR imaging were found in 24/48 (50%) patients. [111In]-octreotide scintigraphy has a higher sensitivity for tumour detection, and is superior to MR imaging and CT scanning in the identification of previously unsuspected extraliver and lymph node metastases. It may also be helpful for the localization of clinically suspected tumours in patients with MEN-I and ZES.