Altered hindlimb extension in the rat after DSP-4: a useful marker of central noradrenergic depletion

Rats treated with DSP-4, a selective noradrenergic neurotoxin, usually exhibited an attenuation of hindlimb extension when suspended by the tail. Those animals showing the reduced extension had no post-decapitation reflex (PDR), whereas those animals having a normal extension had the PDR. On this ba...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 87; no. 2-3; p. 345
Main Authors Mogilnicka, E, Dooley, D J, Boissard, C G, Delini-Stula, A
Format Journal Article
LanguageEnglish
Published Netherlands 18.02.1983
Subjects
Amines - pharmacology
Animals
Behavior, Animal - drug effects
Benzylamines - pharmacology
Brain - drug effects
Clonidine - pharmacology
Drug Interactions
Hindlimb
Male
Neurotoxins - pharmacology
Norepinephrine - physiology
Prazosin - pharmacology
Rats
Rats, Inbred Strains
Yohimbine - pharmacology
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Summary:Rats treated with DSP-4, a selective noradrenergic neurotoxin, usually exhibited an attenuation of hindlimb extension when suspended by the tail. Those animals showing the reduced extension had no post-decapitation reflex (PDR), whereas those animals having a normal extension had the PDR. On this basis, rats injected with DSP-4 can be readily screened for an effective or ineffective noradrenergic lesion. Preliminary evidence suggests that the alpha 2-adrenoceptor is involved in the regulation of hindlimb extension.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(83)90351-5