Studies on ferritin in rat liver and spleen during repeated phlebotomy

1. 1. The ferritin content of liver and spleen in normal and iron-loaded rats decreased during repeated phlebotomy. 2. 2. During increased iron demand, ferritin is degraded in toto. 3. 3. With the ESI and EELS technique the iron distribution was followed in different cell types and cellular compartm...

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Published inInternational journal of biochemistry Vol. 21; no. 1; pp. 39 - 47
Main Authors Mostert, L.J., Cleton, M.I., De Bruijn, W.C., Koster, J.F., Van Eijk, H.G.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 1989
Subjects
Animals
Bloodletting
Cell Compartmentation
Cell Differentiation
Ferritins - metabolism
Iron-Dextran Complex - pharmacology
liver
Liver - metabolism
Liver - ultrastructure
Lysosomes - analysis
Lysosomes - metabolism
Lysosomes - ultrastructure
Male
phlebotomy
Rats
Rats, Inbred Strains
spleen
Spleen - metabolism
Spleen - ultrastructure
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Summary:1. 1. The ferritin content of liver and spleen in normal and iron-loaded rats decreased during repeated phlebotomy. 2. 2. During increased iron demand, ferritin is degraded in toto. 3. 3. With the ESI and EELS technique the iron distribution was followed in different cell types and cellular compartments. 4. 4. We have demonstrated two methods of iron mobilisation: (a) catabolism of lysosomal ferritin in toto and (b) delivery of ferritin from parenchymal cell into the bile and degradation of ferritin in toto.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0020-711X
DOI:10.1016/0020-711X(89)90025-6