Genomic surveillance: a potential shortcut for effective Chagas disease management

Chagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccine...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 117; p. e220164
Main Authors de Azevedo, Sophia Lincoln Cardoso, Catanho, Marcos, Guimarães, Ana Carolina Ramos, Galvão, Teca Calcagno
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.01.2022
Subjects
Chagas Disease - epidemiology
Disease Management
Genomics
Humans
PARASITOLOGY
TROPICAL MEDICINE
Trypanosoma cruzi - genetics
whole genome sequencing
computational biology
Chagas disease
genetic variation
trypanocidal agents
Trypanosoma cruzi
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Summary:Chagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacological technologies rely on the degree of conservation of parasite target proteins. Therefore, there is a need to expand the knowledge regarding parasite genetics which, if fulfilled, could leverage Chagas disease research and development, and improve disease control strategies. The growing capacity of whole-genome sequencing technology and its adoption as disease surveillance routine may be key for solving this long-lasting problem.
Bibliography:ObjectType-Article-1
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ISSN:0074-0276
1678-8060
1678-8060
DOI:10.1590/0074-02760220164