Structure-activity relations of the molluscan neuropeptide FMRFamide on some molluscan muscles

Analogs of the molluscan neuropeptide FMRFamide were tested on four different molluscan muscle preparations which show qualitatively different responses to the peptide; the structure-activity relations are basically similar, but not identical. The C-terminal amide and the Arg3 residue are critical f...

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Bibliographic Details
Published inLife sciences (1973) Vol. 31; no. 22; p. 2471
Main Authors Painter, S D, Morley, J S, Price, D A
Format Journal Article
LanguageEnglish
Published Netherlands 29.11.1982
Subjects
Animals
Dose-Response Relationship, Drug
FMRFamide
Heart - drug effects
Mollusca
Muscles - drug effects
Oligopeptides - pharmacology
Structure-Activity Relationship
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Summary:Analogs of the molluscan neuropeptide FMRFamide were tested on four different molluscan muscle preparations which show qualitatively different responses to the peptide; the structure-activity relations are basically similar, but not identical. The C-terminal amide and the Arg3 residue are critical for FMRFamide-like activity on all four preparations. In contrast, analogs extended at the N-terminal or with conservative substitutions for the Phe1 or Met2 residue are approximately equipotent to FMRFamide. These structural requirements parallel those for the C-terminal tetrapeptide amide of gastrin.
ISSN:0024-3205
DOI:10.1016/0024-3205(82)90752-4