Peptide amidation

Many hormones, neurotransmitters and growth factors are peptides that carry an amide group at their car☐yl terminus which is essential for their biological activity. The amide is formed by hydroxylation of an additional glycine residue present in the biosynthetic precursor and the hydroxyglycine der...

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Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 16; no. 3; pp. 112 - 115
Main Authors Bradbury, Alan F., Smyth, Derek G.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1991
Subjects
amidation
Amidine-Lyases
Amination
Animals
Hydro-Lyases - metabolism
Mixed Function Oxygenases - metabolism
Models, Chemical
Multienzyme Complexes
Peptides - metabolism
Protein Processing, Post-Translational
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Summary:Many hormones, neurotransmitters and growth factors are peptides that carry an amide group at their car☐yl terminus which is essential for their biological activity. The amide is formed by hydroxylation of an additional glycine residue present in the biosynthetic precursor and the hydroxyglycine derivative dissociates to form the peptide amide and glyoxylic acid. Recent discoveries have shown that two enzymes are involved that act sequentially.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0968-0004
1362-4326
DOI:10.1016/0968-0004(91)90044-V