Suppression of the hepatic glucose-6-phosphatase system in diabetic rats by vanadate

• Published in: Annals of nutrition and metabolism Vol. 32; no. 5-6; p. 289
• Main Author: Schulz, L O
• Format: Journal Article
• Language: English
• Published: Switzerland 1988
• Subjects: Animals; Blood Glucose - analysis; Diabetes Mellitus, Experimental - enzymology; Glucose-6-Phosphatase - antagonists & inhibitors; Hydrolysis; Kinetics; Liver - drug effects; Liver - enzymology; Male; Rats; Rats, Inbred Strains; Vanadates - pharmacology

The effect of oral administration of vanadate on the transport and hydrolytic components of the glucose-6-phosphatase system in liver homogenates from streptozotocin-induced diabetic rats was examined. Blood glucose was normalized in diabetic rats receiving 0.8 mg/ml vanadate but a catabolic effect...