Suppression of the hepatic glucose-6-phosphatase system in diabetic rats by vanadate

The effect of oral administration of vanadate on the transport and hydrolytic components of the glucose-6-phosphatase system in liver homogenates from streptozotocin-induced diabetic rats was examined. Blood glucose was normalized in diabetic rats receiving 0.8 mg/ml vanadate but a catabolic effect...

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Bibliographic Details
Published inAnnals of nutrition and metabolism Vol. 32; no. 5-6; p. 289
Main Author Schulz, L O
Format Journal Article
LanguageEnglish
Published Switzerland 1988
Subjects
Animals
Blood Glucose - analysis
Diabetes Mellitus, Experimental - enzymology
Glucose-6-Phosphatase - antagonists & inhibitors
Hydrolysis
Kinetics
Liver - drug effects
Liver - enzymology
Male
Rats
Rats, Inbred Strains
Vanadates - pharmacology
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Summary:The effect of oral administration of vanadate on the transport and hydrolytic components of the glucose-6-phosphatase system in liver homogenates from streptozotocin-induced diabetic rats was examined. Blood glucose was normalized in diabetic rats receiving 0.8 mg/ml vanadate but a catabolic effect was observed on body and liver weight. Significant changes in the coupled reactions for glucose-6-phosphate transport by T1 and hydrolysis by the enzyme were noted. The dramatic elevation in the maximal velocity of glucose-6-phosphatase brought about by diabetes was suppressed by vanadate administration. As a result, the relationship between T1 and the enzyme returned to the normal range. It is concluded that the suppression of glucose-6-phosphate hydrolysis in diabetes may contribute to the normalizing effect of vanadate on blood glucose.
ISSN:0250-6807
DOI:10.1159/000177469