Suppression of the hepatic glucose-6-phosphatase system in diabetic rats by vanadate
The effect of oral administration of vanadate on the transport and hydrolytic components of the glucose-6-phosphatase system in liver homogenates from streptozotocin-induced diabetic rats was examined. Blood glucose was normalized in diabetic rats receiving 0.8 mg/ml vanadate but a catabolic effect...
Saved in:
Published in | Annals of nutrition and metabolism Vol. 32; no. 5-6; p. 289 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
Switzerland
1988
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | The effect of oral administration of vanadate on the transport and hydrolytic components of the glucose-6-phosphatase system in liver homogenates from streptozotocin-induced diabetic rats was examined. Blood glucose was normalized in diabetic rats receiving 0.8 mg/ml vanadate but a catabolic effect was observed on body and liver weight. Significant changes in the coupled reactions for glucose-6-phosphate transport by T1 and hydrolysis by the enzyme were noted. The dramatic elevation in the maximal velocity of glucose-6-phosphatase brought about by diabetes was suppressed by vanadate administration. As a result, the relationship between T1 and the enzyme returned to the normal range. It is concluded that the suppression of glucose-6-phosphate hydrolysis in diabetes may contribute to the normalizing effect of vanadate on blood glucose. |
---|---|
ISSN: | 0250-6807 |
DOI: | 10.1159/000177469 |