An interspecific backcross linkage map of mouse chromosome 8

We have established a 67-cM molecular genetic linkage map of mouse chromosome 8 by interspecific backcross analysis. Genes that were mapped in this study include Act-6, Aprt, Aprt-ps1, Emv-2, Es-N, Hp, Insr, Mt-1, Plat, Psx-8, Ucp, and Zfp-4. New regions of homology were established between mouse ch...

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Published inGenomics (San Diego, Calif.) Vol. 6; no. 1; pp. 72 - 79
Main Authors Ceci, Jeffrey D., Justice, Monica J., Lock, Leslie F., Jenkins, Nancy A., Copeland, Neal G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1990
Subjects
Animals
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Crosses, Genetic
DNA Probes
Genetic Linkage
Humans
Mice - genetics
Mice, Inbred C57BL
Polymorphism, Restriction Fragment Length
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Summary:We have established a 67-cM molecular genetic linkage map of mouse chromosome 8 by interspecific backcross analysis. Genes that were mapped in this study include Act-6, Aprt, Aprt-ps1, Emv-2, Es-N, Hp, Insr, Mt-1, Plat, Psx-8, Ucp, and Zfp-4. New regions of homology were established between mouse chromosome 8 and human chromosomes 8 and 19. A conserved linkage group was identified between mouse chromosome 8 and human chromosome 16. The map will be useful for establishing linkage of other markers to mouse chromosome 8.
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ISSN:0888-7543
1089-8646
DOI:10.1016/0888-7543(90)90449-5