Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer's Disease Brains

• Published in: Journal of Alzheimer's disease Vol. 61; no. 1; p. 209
• Main Authors: Villamil-Ortiz, Javier Gustavo, Barrera-Ocampo, Alvaro, Arias-Londoño, Julián David, Villegas, Andrés, Lopera, Francisco, Cardona-Gómez, Gloria Patricia
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2018
• Subjects: Adult; Aged; Aged, 80 and over; Alanine - genetics; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Analysis of Variance; Fatty Acids - metabolism; Female; Gene Expression Regulation - genetics; Glutamic Acid - genetics; Humans; Lysophosphatidylcholines - metabolism; Male; Mass Spectrometry; Middle Aged; Mutation - genetics; Phosphatidylethanolamines - metabolism; Phospholipids - metabolism; Presenilin-1 - genetics; Temporal Lobe - metabolism; phospholipids; Alzheimer’s disease; fatty acids; temporal cortex; polyunsaturated fatty acids
• ISSN: 1875-8908
• DOI: 10.3233/JAD-170554

Lipids are considered important factors in the pathogenesis of Alzheimer's disease (AD). In this study, we realized a comparative analysis of the phospholipid profile and phospholipid composition of the temporal cortex from E280A-familiar AD (FAD), sporadic AD (SAD), and healthy human brains. Findings showed a significant decrease of lysophosphatidylcholine and phosphatidylethanolamine formed by low levels of polyunsaturated fatty acids (20 : 4, 22 : 6) in AD brains. However, phosphatidylethanolamine-ceramide and phosphoglycerol were significantly increased in SAD, conformed by high levels of (18 : 0/18 : 1) and (30/32/36 : 0/1/2), respectively. Together, the findings suggest a deficiency in lysophosphacholine and phosphatidylethanolamine, and alteration in the balance between poly- and unsaturated fatty acids in both types of AD, and a differential pattern of phospholipid profile and fatty acid composition between E280A FAD and SAD human brains.