Alpha-fetoprotein and phagocytosis in athymic nude mice

Alpha-fetoprotein (AFP) was found to suppress the phagocytic activity of the blood monocytes and neutrophils in vitro. The amounts of AFP detectable by immunofluorescence in the livers of nu/nu, nu/+ and +/+ mice were quite comparable, and thus could not have been responsible for the alterations in...

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Bibliographic Details
Published inImmunology letters Vol. 19; no. 2; pp. 95 - 98
Main Authors Větvička, V., Holub, M., Kovářů, H., Šiman, P., Kovářů, F.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.1988
Subjects
Age Factors
Alpha-fetoprotein
alpha-Fetoproteins - immunology
alpha-Fetoproteins - metabolism
alpha-Fetoproteins - pharmacology
Animals
In Vitro Techniques
Liver - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Nude
Nude mice
Phagocytes - drug effects
Phagocytes - immunology
phagocytosis
Phagocytosis - drug effects
Nude mice
phagocytosis
Alpha-fetoprotein
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Summary:Alpha-fetoprotein (AFP) was found to suppress the phagocytic activity of the blood monocytes and neutrophils in vitro. The amounts of AFP detectable by immunofluorescence in the livers of nu/nu, nu/+ and +/+ mice were quite comparable, and thus could not have been responsible for the alterations in phagocytosis found in leukocytes of athymic nude mice during their ontogenetic development.
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ISSN:0165-2478
1879-0542
DOI:10.1016/0165-2478(88)90125-3