Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

• Published in: Neurobiology of aging Vol. 21; no. 4; pp. 503 - 510
• Main Authors: Schwab, Claudia, DeMaggio, Anthony J., Ghoshal, Nupur, Binder, Lester I., Kuret, Jeff, McGeer, Patrick L.
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.07.2000; Elsevier Science
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer’s disease; Amyotrophic Lateral Sclerosis - metabolism; Amyotrophic Lateral Sclerosis - pathology; Antibody Specificity; Biological and medical sciences; Brain - enzymology; Brain - pathology; casein kinase; Casein kinase 1 delta; Casein Kinases; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Granulovacuolar bodies; Humans; Immunocytochemistry; Immunohistochemistry; Inclusion Bodies - chemistry; Inclusion Bodies - enzymology; Lewy bodies; Lewy Bodies - chemistry; Lewy Bodies - enzymology; Male; Medical sciences; Middle Aged; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurofibrillary and glial tangles; Neurofibrillary Tangles - chemistry; Neurofibrillary Tangles - enzymology; Neuroglia - chemistry; Neuroglia - enzymology; Neurology; Pallido-ponto-nigral degeneration; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinsonism dementia complex of Guam; Parkinson’s disease; Pick’s disease; Protein Kinases - analysis; Protein Kinases - immunology; Protein Kinases - metabolism; tau Proteins - analysis; tau Proteins - immunology; tau Proteins - metabolism; Casein kinase 1 delta; Alzheimer’s disease; Neurofibrillary and glial tangles; Granulovacuolar bodies; Immunocytochemistry; Pallido-ponto-nigral degeneration; Parkinsonism dementia complex of Guam; Pick’s disease; Parkinson’s disease; Lewy bodies; Human; Nervous system diseases; Enzyme; Protein kinase; Transferases; Degenerative disease; Biological accumulation
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/S0197-4580(00)00110-X

The distribution of casein kinase 1 δ (Ckiδ) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer’s disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick’s disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Ckiδ was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and “skein”-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Ckiδ and its apparent substrate tau suggests a function for Ckiδ in the abnormal processing of tau.