Psoriasis

Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential thera...

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Bibliographic Details
Published inAnnual review of pathology Vol. 7; p. 385
Main Authors Perera, Gayathri K, Di Meglio, Paola, Nestle, Frank O
Format Journal Article
LanguageEnglish
Published United States 01.01.2012
Subjects
Cytokines - antagonists & inhibitors
Cytokines - immunology
Humans
Psoriasis - drug therapy
Psoriasis - genetics
Psoriasis - immunology
Psoriasis - pathology
Skin - pathology
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Summary:Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies.
ISSN:1553-4014
DOI:10.1146/annurev-pathol-011811-132448