Fetal lamb clearance of morphine as determined by high performance liquid chromatography with electrochemical detection

Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.

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Published inNeuropeptides (Edinburgh) Vol. 5; no. 1; pp. 77 - 80
Main Authors Olsen, George D, Ousley, Paula J, Mathis, Mark D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.01.1984
Subjects
Animals
Chromatography, High Pressure Liquid - methods
Female
Fetal Blood - metabolism
Metabolic Clearance Rate
Morphine - blood
Pregnancy
Sheep
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Abstract Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
AbstractList Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 plus or minus 6 ml. min 1.kg super(-1), was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 +/- 6 ml.min-1.kg-1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
Author Olsen, George D
Ousley, Paula J
Mathis, Mark D
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Cites_doi 10.1021/ac50058a041
10.1016/0024-3205(83)90611-2
10.1016/S0021-9673(00)89711-3
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References Olsen, Hohimer, Mathis (BIB3) 1983; 33
White (BIB5) 1979; 178
Bioanalytical Systems, Inc (BIB4) 1982
Berkowitz, Cerreta, Spector (BIB2) 1974; 191
Szeto, Umans, MacFarland (BIB1) 1982; 143
Wallace, Harris, Peek (BIB6) 1980; 52
Berkowitz (10.1016/0143-4179(84)90031-3_BIB2) 1974; 191
Wallace (10.1016/0143-4179(84)90031-3_BIB6) 1980; 52
Szeto (10.1016/0143-4179(84)90031-3_BIB1) 1982; 143
Bioanalytical Systems, Inc (10.1016/0143-4179(84)90031-3_BIB4) 1982
White (10.1016/0143-4179(84)90031-3_BIB5) 1979; 178
Olsen (10.1016/0143-4179(84)90031-3_BIB3) 1983; 33
References_xml – year: 1982
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  ident: BIB2
  article-title: The influence of physiologic and pharmacologic factors on the disposition of morphine as determined by radioimmunoassay
  publication-title: Journal of Pharmacology and Experimental Therapeutics
  contributor:
    fullname: Spector
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  article-title: A comparison of morphine and methadone disposition in the maternal-fetal unit. American
  publication-title: Journal of Obstetrics and Gynecology
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  article-title: Determination of morphine by liquid chromatography with electrochemical detection
  publication-title: Analytical Chemistry
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    fullname: Peek
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  article-title: Cerebral blood flow and metabolism during morphine-induced stimulation of breathing movements in fetal lambs
  publication-title: Life Sciences
  contributor:
    fullname: Mathis
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  end-page: 240
  ident: BIB5
  article-title: Determination of morphine and its major metabolite, morphine-3-glucuronide, in blood by high-performance liquid chromatography with electrochemical detection
  publication-title: Journal of Chromatography
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– volume: 191
  start-page: 527
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  ident: 10.1016/0143-4179(84)90031-3_BIB2
  article-title: The influence of physiologic and pharmacologic factors on the disposition of morphine as determined by radioimmunoassay
  publication-title: Journal of Pharmacology and Experimental Therapeutics
  contributor:
    fullname: Berkowitz
– volume: 52
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  ident: 10.1016/0143-4179(84)90031-3_BIB6
  article-title: Determination of morphine by liquid chromatography with electrochemical detection
  publication-title: Analytical Chemistry
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– volume: 33
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  issue: Sup. I
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  ident: 10.1016/0143-4179(84)90031-3_BIB3
  article-title: Cerebral blood flow and metabolism during morphine-induced stimulation of breathing movements in fetal lambs
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  ident: 10.1016/0143-4179(84)90031-3_BIB5
  article-title: Determination of morphine and its major metabolite, morphine-3-glucuronide, in blood by high-performance liquid chromatography with electrochemical detection
  publication-title: Journal of Chromatography
  doi: 10.1016/S0021-9673(00)89711-3
  contributor:
    fullname: White
– volume: 143
  start-page: 700
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  ident: 10.1016/0143-4179(84)90031-3_BIB1
  article-title: A comparison of morphine and methadone disposition in the maternal-fetal unit. American
  publication-title: Journal of Obstetrics and Gynecology
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    fullname: Szeto
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  ident: 10.1016/0143-4179(84)90031-3_BIB4
  contributor:
    fullname: Bioanalytical Systems, Inc
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Snippet Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was...
Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 +/- 6 ml.min-1.kg-1, was...
Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 plus or minus 6 ml. min 1.kg...
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SubjectTerms Animals
Chromatography, High Pressure Liquid - methods
Female
Fetal Blood - metabolism
Metabolic Clearance Rate
Morphine - blood
Pregnancy
Sheep
Title Fetal lamb clearance of morphine as determined by high performance liquid chromatography with electrochemical detection
URI https://dx.doi.org/10.1016/0143-4179(84)90031-3
https://www.ncbi.nlm.nih.gov/pubmed/6531079
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