Fetal lamb clearance of morphine as determined by high performance liquid chromatography with electrochemical detection

Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.

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Bibliographic Details
Published inNeuropeptides (Edinburgh) Vol. 5; no. 1; pp. 77 - 80
Main Authors Olsen, George D, Ousley, Paula J, Mathis, Mark D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.01.1984
Subjects
Animals
Chromatography, High Pressure Liquid - methods
Female
Fetal Blood - metabolism
Metabolic Clearance Rate
Morphine - blood
Pregnancy
Sheep
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Summary:Morphine clearance from plasma was determined during constant r a te d r ug infusion in 10 late gestation fetal lambs. Clearance, 65 ± 6 ml.min 1.kg 1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
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ISSN:0143-4179
1532-2785
DOI:10.1016/0143-4179(84)90031-3