RNA Degradation in Saccharomyces cerevisae

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs, and noncoding RNAs. In addition, numerous quality control mechanisms that target aberrant RNAs have been identified. Generally, ea...

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Bibliographic Details
Published inGenetics (Austin) Vol. 191; no. 3; pp. 671 - 702
Main Author Parker, Roy
Format Journal Article
LanguageEnglish
Published United States Genetics Society of America 01.07.2012
Subjects
Animals
Cytoplasm - genetics
Cytoplasm - metabolism
Quality control
Ribonucleic acid
RNA
RNA Stability
RNA, Fungal - chemistry
RNA, Fungal - genetics
RNA, Fungal - metabolism
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Yeast
YeastBook
Yeasts
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Summary:All RNA species in yeast cells are subject to turnover. Work over the past 20 years has defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs, and noncoding RNAs. In addition, numerous quality control mechanisms that target aberrant RNAs have been identified. Generally, each decay mechanism contains factors that funnel RNA substrates to abundant exo- and/or endonucleases. Key issues for future work include determining the mechanisms that control the specificity of RNA degradation and how RNA degradation processes interact with translation, RNA transport, and other cellular processes.
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ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.111.137265