Suppression of anaphylactic shock in sensitized guinea pigs by cytochalasin B

Twenty-three guinea pigs, presensitized with horse serum, were injected intracardially with 1ml of 1.5× 10 −4 M cytochalasin B in a 2.5% dimethyl sulfoxide solution, 1.5 h before being challenged with the serum. Eighteen of the guinea pigs (80%) survived. A single intracardiac injection of cytochala...

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Bibliographic Details
Published inImmunology letters Vol. 22; no. 3; pp. 193 - 194
Main Authors Stefani, D.V., Veltishchev, Yu.E., Semyonov, A.V., Kudrina, G.P.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.1989
Subjects
Anaphylactic shock
Anaphylaxis - prevention & control
Animals
Cytochalasin B
Cytochalasin B - administration & dosage
Cytochalasin B - pharmacology
Cytoskeleton
Guinea Pigs
Mast cells
Mediators
Cytoskeleton
Mast cells
Mediators
Anaphylactic shock
Cytochalasin B
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Summary:Twenty-three guinea pigs, presensitized with horse serum, were injected intracardially with 1ml of 1.5× 10 −4 M cytochalasin B in a 2.5% dimethyl sulfoxide solution, 1.5 h before being challenged with the serum. Eighteen of the guinea pigs (80%) survived. A single intracardiac injection of cytochalasin B to the control group of guinea pigs at 1.5 h before administration of the allergen did not prevent their sensitization and death following challenge.
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ISSN:0165-2478
1879-0542
DOI:10.1016/0165-2478(89)90189-2