Contractile activity of vasotocin, oxytocin, and vasopressin on mammalian prostate

The neurohypophyseal peptides arginine vasotocin, oxytocin and arginine vasopressin contracted guinea pig, rat, canine and human prostates with potencies and efficacies that were comparable to those of noradrenaline and methacholine. All three neuropeptides raised prostatic tone and elicited contrac...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 216; no. 2; p. 311
Main Authors Bodanszky, M, Sharaf, H, Roy, J B, Said, S I
Format Journal Article
LanguageEnglish
Published Netherlands 05.06.1992
Subjects
Animals
Dogs
Guinea Pigs
Humans
Male
Muscle Contraction - drug effects
Oxytocin - pharmacology
Prostate - drug effects
Rats
Rats, Sprague-Dawley
Vasopressins - pharmacology
Vasotocin - pharmacology
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Summary:The neurohypophyseal peptides arginine vasotocin, oxytocin and arginine vasopressin contracted guinea pig, rat, canine and human prostates with potencies and efficacies that were comparable to those of noradrenaline and methacholine. All three neuropeptides raised prostatic tone and elicited contractions at 10(-9) or 10(-8) M, with an order of efficacy: arginine vasotocin greater than oxytocin greater than arginine vasopressin. The findings suggest a physiological role for these peptides in prostatic smooth muscle contraction and possibly also in other aspects of male reproductive function.
ISSN:0014-2999
DOI:10.1016/0014-2999(92)90376-F