Acute effects of oral glucose loading on the renin-angiotensin-aldosterone system in patients with chronic renal disease

To determine the changes of the glucose-induced renin-angiotensin-aldosterone system in chronic renal disease, a standard oral glucose loading test (75g) was performed in patients with chronic glomerulonephritis (CGN) (n = 12) and compared with control subjects (10). Glucose loading resulted in a si...

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Bibliographic Details
Published inHormone and metabolic research Vol. 25; no. 2; p. 110
Main Authors Uemasu, J, Fujihara, M, Matsumoto, T, Kawasaki, H
Format Journal Article
LanguageEnglish
Published Germany 01.02.1993
Subjects
Adult
Aldosterone - blood
Blood Glucose - metabolism
Chronic Disease
Creatinine - blood
Glomerulonephritis - metabolism
Glucose - pharmacology
Humans
Insulin - blood
Middle Aged
Potassium - urine
Renin - blood
Renin-Angiotensin System - drug effects
Sodium - urine
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Summary:To determine the changes of the glucose-induced renin-angiotensin-aldosterone system in chronic renal disease, a standard oral glucose loading test (75g) was performed in patients with chronic glomerulonephritis (CGN) (n = 12) and compared with control subjects (10). Glucose loading resulted in a significant decrease of serum aldosterone as well as increases of blood glucose and insulin similarly in both CGN and C. However, the suppression of aldosterone was statistically milder in CGN than in C (p < 0.05). In contrast, significant elevations of plasma renin activity were observed in CGN at 60 and 120 min, but not in C after glucose loading. Urinary sodium excretion after glucose ingestion was lower in CGN than in C. These data demonstrated that the glucose-induced renin-angiotensin-aldosterone system in patients with chronic renal disease differed from that in healthy subjects.
ISSN:0018-5043
DOI:10.1055/s-2007-1002054