Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of...

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Bibliographic Details
Published inThe Journal of pharmacology and experimental therapeutics Vol. 362; no. 3; pp. 474 - 488
Main Authors Moszczynska, Anna, Callan, Sean Patrick
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2017
Subjects
Amphetamine-Related Disorders - drug therapy
Animals
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - drug therapy
Dopaminergic Neurons - drug effects
Dose-Response Relationship, Drug
Humans
Methamphetamine - pharmacology
Methamphetamine - toxicity
Neural Pathways - drug effects
Neurotoxicity Syndromes - complications
Neurotoxicity Syndromes - drug therapy
Serotonergic Neurons - drug effects
DAergic
5HT
ADHD
METH
5HTergic
CNS
ZSET1446
PFC
TPH
GLU
SERT
NEergic
PD
TH
DAT
NE
VMAT2
GLUergic
DA
PET
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Summary:Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses, and discusses implications of METH neurotoxicity for treatment of human abusers of the drug.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0022-3565
1521-0103
1521-0103
DOI:10.1124/jpet.116.238501