Kindling antagonism: interactions of the amygdala with the piriform, perirhinal, and insular cortices

• Published in: Brain research Vol. 733; no. 2; pp. 211 - 218
• Main Authors: Mohapel, Paul, Corcoran, Michael E
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.09.1996
• Subjects: Amygdala; Amygdala - physiology; Amygdala - physiopathology; Animals; Brain Mapping; Cerebral Cortex - physiology; Cerebral Cortex - physiopathology; Electric Stimulation; Insular cortex; Kindling; Kindling antagonism; Kindling, Neurologic; Limbic System - physiology; Limbic System - physiopathology; Male; Perirhinal cortex; Piriform cortex; Rats; Seizure suppression; Seizures - physiopathology; Seizure suppression; Amygdala; Kindling; Piriform cortex; Perirhinal cortex; Kindling antagonism; Insular cortex
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/0006-8993(96)00544-6

We employed the kindling antagonism paradigm to characterize the role of the amygdala (AM), piriform cortex (PIR), perirhinal cortex (PRH), and insular cortex (INS) in the propagation and expression of generalized seizures. Alternating kindling stimulation was delivered to the AM and either the PIR, PRH, or INS. We found that kindling from the AM was retarded by stimulation only of the deep layers of both the INS and anterior PRH. Kindling antagonism was specific to the anterior cortical regions, since neither the posterior PRH or PIR were capable of antagonizing AM kindling. The results strongly implicate the deep layers of anterior limbic cortex in establishment of antagonism of AM kindling.